Integrin alpha 6 beta 1 (ITGA6&ITGB1) Heterodimer[Biotin], His & Avi, Human
Integrin Alpha 6 Beta 1 (ITGA6&ITGB1) Heterodimer[Biotin], His & Avi, Human

Integrin alpha 6 beta 1 (ITGA6&ITGB1) Heterodimer[Biotin], His & Avi, Human on Bis-Tris PAGE under Non reducing (N) condition. The purity is greater than 95%.

Integrin alpha 6 beta 1 (ITGA6&ITGB1) Heterodimer[Biotin], His & Avi, Human

Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling
Z04519
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Product Introduction
Species Human
Protein Construction
Integrin alpha 6 beta 1 (ITGA6&ITGB1) Heterodimer [Phe24-Gly1012 (ITGA6) acidic tail and GIn21-Asp728 (ITGB1) basic tail]
Accession # P23229-2 (ITGA6) & P05556-1 (ITGB1)		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 117.9 kDa (ITGA6) and 83.2 kDa (ITGB1)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 140-160 kDa (ITGA6) and 110-150 kDa (ITGB1) under Non reducing (N) condition based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • Integrin Alpha 6 Beta 1 (ITGA6&ITGB1) Heterodimer[Biotin], His & Avi, Human
    • Integrin Alpha 6 Beta 1 (ITGA6&ITGB1) Heterodimer[Biotin], His & Avi, Human

    Integrin alpha 6 beta 1 (ITGA6&ITGB1) Heterodimer[Biotin], His & Avi, Human on Bis-Tris PAGE under Non reducing (N) condition. The purity is greater than 95%.


Background
Target Background Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling
Synonyms α6β1; Integrin alpha 6 beta 1; ITGA6&ITGB1;Integrin alpha 6 β 1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.