IL-6 R alpha/CD126[Biotin], His & Avi, Human
IL-6 R Alpha/CD126[Biotin], His & Avi, Human

Immobilized Human IL-6, No Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for IL-6 R alpha/CD126[Biotin], His & Avi, Human, His Tag with the EC50 of 0.88 μg/ml determined by ELISA.

IL-6 R Alpha/CD126[Biotin], His & Avi, Human

The purity of IL-6 R alpha/CD126[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

IL-6 R Alpha/CD126[Biotin], His & Avi, Human

IL-6 R alpha/CD126[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-6 R alpha/CD126[Biotin], His & Avi, Human

The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6R alpha) and a signal-transducing component of 130 kDa (gp130) that does not bind IL-6 by itself, but is required for high-affinity binding of IL-6 by the complex. Both components of the receptor complex, IL-6R alpha and gp130 have been cloned, sequenced, and expressed.
Z04517
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Product Introduction
Species Human
Protein Construction
IL-6 R alpha/CD126 (Leu20-Pro365)
Accession # P08887-1		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Human IL­6, No Tag at 5μg/ml (100μl/well) on the plate can bind IL-6 R alpha/CD126[Biotin], His & Avi, Human. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 41.4 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • IL-6 R Alpha/CD126[Biotin], His & Avi, Human
    • IL-6 R Alpha/CD126[Biotin], His & Avi, Human

    Immobilized Human IL-6, No Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for IL-6 R alpha/CD126[Biotin], His & Avi, Human, His Tag with the EC50 of 0.88 μg/ml determined by ELISA.

  • IL-6 R Alpha/CD126[Biotin], His & Avi, Human
    • IL-6 R Alpha/CD126[Biotin], His & Avi, Human

    The purity of IL-6 R alpha/CD126[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • IL-6 R Alpha/CD126[Biotin], His & Avi, Human
    • IL-6 R Alpha/CD126[Biotin], His & Avi, Human

    IL-6 R alpha/CD126[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6R alpha) and a signal-transducing component of 130 kDa (gp130) that does not bind IL-6 by itself, but is required for high-affinity binding of IL-6 by the complex. Both components of the receptor complex, IL-6R alpha and gp130 have been cloned, sequenced, and expressed.
Synonyms IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1; IL6R; CD126; IL6RQ; gp80

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.