IL-3 R alpha/CD123[Biotin], His & Avi, Human
IL-3 R Alpha/CD123[Biotin], His & Avi, Human

Immobilized Anti-IL-3 R alpha Antibody, hFc Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for IL-3 R alpha/CD123[Biotin], His & Avi, Human, His Tag with the EC50 of 16.7 ng/ml determined by ELISA.

IL-3 R Alpha/CD123[Biotin], His & Avi, Human

The purity of IL-3 R alpha/CD123[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

IL-3 R Alpha/CD123[Biotin], His & Avi, Human

IL-3 R alpha/CD123[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-3 R alpha/CD123[Biotin], His & Avi, Human

Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 5 subfamily.The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias.
Z04513
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Product Introduction
Species Human
Protein Construction
L-3 R alpha/CD123 (Thr19-Arg305)
Accession # P26951-1		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Anti­IL­3 R alpha Antibody, hFc Tag at 1μg/ml (100μl/well) on the plate can bind IL-3 R alpha/CD123[Biotin], His & Avi, Human. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 35.99 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • IL-3 R Alpha/CD123[Biotin], His & Avi, Human
    • IL-3 R Alpha/CD123[Biotin], His & Avi, Human

    Immobilized Anti-IL-3 R alpha Antibody, hFc Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for IL-3 R alpha/CD123[Biotin], His & Avi, Human, His Tag with the EC50 of 16.7 ng/ml determined by ELISA.

  • IL-3 R Alpha/CD123[Biotin], His & Avi, Human
    • IL-3 R Alpha/CD123[Biotin], His & Avi, Human

    The purity of IL-3 R alpha/CD123[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • IL-3 R Alpha/CD123[Biotin], His & Avi, Human
    • IL-3 R Alpha/CD123[Biotin], His & Avi, Human

    IL-3 R alpha/CD123[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 5 subfamily.The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias.
Synonyms CD123; IL-3R subunit alpha; IL3R; IL3RA; IL-3Ra; IL3RAY; IL3RX; IL3RY; MGC34174; IL-3 R alpha

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.