IL-1 Beta/IL-1F2[Biotin], His & Avi, Human
IL-1 Beta/IL-1F2[Biotin], His & Avi, Human

Immobilized Human IL-1 RII, hFc Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for IL-1 Beta/IL-1F2[Biotin], His & Avi, Human, His-Avi Tag with the EC50 of 7.8ng/ml determined by ELISA.

IL-1 Beta/IL-1F2[Biotin], His & Avi, Human

The purity of IL-1 Beta/IL-1F2[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

IL-1 Beta/IL-1F2[Biotin], His & Avi, Human

IL-1 Beta/IL-1F2[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-1 Beta/IL-1F2[Biotin], His & Avi, Human

Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells.
Z04487
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Product Introduction
Species Human
Protein Construction
IL-1 Beta/IL-1F2 (Ala117-Ser269)
Accession # P01584		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1 EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Human IL­1R2, hFc Tag at 1 μg/ml (100 μl/well) on the plate can bind IL-1 Beta/IL-1F2[Biotin], His & Avi, Human. Test result was comparable to standard batch.
Expression System E.coil
Theoretical Molecular Weight 20.1 kDa
Apparent Molecular Weight The protein has a predicted MW of 20.1 kDa same as Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • IL-1 Beta/IL-1F2[Biotin], His & Avi, Human
    • IL-1 Beta/IL-1F2[Biotin], His & Avi, Human

    Immobilized Human IL-1 RII, hFc Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for IL-1 Beta/IL-1F2[Biotin], His & Avi, Human, His-Avi Tag with the EC50 of 7.8ng/ml determined by ELISA.

  • IL-1 Beta/IL-1F2[Biotin], His & Avi, Human
    • IL-1 Beta/IL-1F2[Biotin], His & Avi, Human

    The purity of IL-1 Beta/IL-1F2[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • IL-1 Beta/IL-1F2[Biotin], His & Avi, Human
    • IL-1 Beta/IL-1F2[Biotin], His & Avi, Human

    IL-1 Beta/IL-1F2[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells.
Synonyms Interleukin-1 beta; IL-1 beta; IL1F2; IL1B; IL-1BETA; IL1F2; IL-1β; IL-1 beta; IL-1B ;Interleukin-1 β; IL-1 β; IL-1β; IL-1 β

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.