IGF1R/CD221[Biotin], His & Avi, Human
IGF1R/CD221[Biotin], His & Avi, Human

Immobilized IGF1R/CD221[Biotin], His & Avi, Human, His Tag at 5 μg/ml (100 μl/Well) on streptavidin(5 μg/ml) precoated plate. Dose response curve for Human IGFI, hFc Tag with the EC50 of 0.79 μg/ml determined by ELISA.

IGF1R/CD221[Biotin], His & Avi, Human

The purity of IGF1R/CD221[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

IGF1R/CD221[Biotin], His & Avi, Human

IGF1R/CD221[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IGF1R/CD221[Biotin], His & Avi, Human

The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.
Z04484
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Product Introduction
Species Human
Protein Construction
IGF1R/CD221 (Glu31-Asn932)
Accession # P08069		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized IGF1R/CD221[Biotin], His & Avi, Human at 5μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml) can bind Human IGF­I, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 105.8 kDa (alpha subunit) and 23 kDa (beta subunit)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 110-120 kDa (alpha subunit) and 52-55 kDa (beta subunit) based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • IGF1R/CD221[Biotin], His & Avi, Human
    • IGF1R/CD221[Biotin], His & Avi, Human

    Immobilized IGF1R/CD221[Biotin], His & Avi, Human, His Tag at 5 μg/ml (100 μl/Well) on streptavidin(5 μg/ml) precoated plate. Dose response curve for Human IGFI, hFc Tag with the EC50 of 0.79 μg/ml determined by ELISA.

  • IGF1R/CD221[Biotin], His & Avi, Human
    • IGF1R/CD221[Biotin], His & Avi, Human

    The purity of IGF1R/CD221[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • IGF1R/CD221[Biotin], His & Avi, Human
    • IGF1R/CD221[Biotin], His & Avi, Human

    IGF1R/CD221[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.
Synonyms CD221; IGF1R; IGF-1R; IGF-I R; IGF-I receptor; IGFIR; IGFR; JTK13; MGC142170; MGC142172; MGC18216

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.