IFN alpha/beta R2[Biotin], His & Avi, Human
IFN Alpha/beta R2[Biotin], His & Avi, Human

The purity of IFN alpha/beta R2[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

IFN Alpha/beta R2[Biotin], His & Avi, Human

IFN alpha/beta R2[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IFN Alpha/beta R2[Biotin], His & Avi, Human

IFN alpha/beta R2[Biotin], His & Avi, Human, His-Avi Tag captured on CM5 Chip via anti-his antibody can bind Human IFN alpha 1, hFc Tag with an affinity constant of 24.2 nM as determined in SPR assay (Biacore T200).

IFN alpha/beta R2[Biotin], His & Avi, Human

Although interferon (IFN)-α is known to exert immunomodulatory and antiproliferative effects on dendritic cells (DCs) through induction of protein-coding IFN-stimulated genes (ISGs), little is known about IFN-α-regulated miRNAs in DCs. Since several miRNAs are involved in regulating DC functions, it is important to investigate whether IFN-α's effects on DCs are mediated through miRNAs as well.
Z04481
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Product Introduction
Species Human
Protein Construction
IFN alpha/beta R2 (Ile27-Lys243)
Accession # P48551-2		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Loaded IFN alpha/beta R2[Biotin], His & Avi, Human on Anti-­His­-Biosensor can bind Human IFN alpha 1, hFc Tag in BLI assay (Gator® Prime). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 27.66 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 42-52 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • IFN Alpha/beta R2[Biotin], His & Avi, Human
    • IFN Alpha/beta R2[Biotin], His & Avi, Human

    The purity of IFN alpha/beta R2[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • IFN Alpha/beta R2[Biotin], His & Avi, Human
    • IFN Alpha/beta R2[Biotin], His & Avi, Human

    IFN alpha/beta R2[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • IFN Alpha/beta R2[Biotin], His & Avi, Human
    • IFN Alpha/beta R2[Biotin], His & Avi, Human

    IFN alpha/beta R2[Biotin], His & Avi, Human, His-Avi Tag captured on CM5 Chip via anti-his antibody can bind Human IFN alpha 1, hFc Tag with an affinity constant of 24.2 nM as determined in SPR assay (Biacore T200).


Background
Target Background Although interferon (IFN)-α is known to exert immunomodulatory and antiproliferative effects on dendritic cells (DCs) through induction of protein-coding IFN-stimulated genes (ISGs), little is known about IFN-α-regulated miRNAs in DCs. Since several miRNAs are involved in regulating DC functions, it is important to investigate whether IFN-α's effects on DCs are mediated through miRNAs as well.
Synonyms IFN-R-2; IFNAR2; IFNARB; IFNABR; IFN-alpha; IFN-alpha/beta R2; IFNbR2; IFN-R; β receptor 2; β receptor10

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.