IFN alpha/beta R1[Biotin], His & Avi, Human
IFN Alpha/beta R1[Biotin], His & Avi, Human

Immobilized Anti-IFN-alpha R1 Antibody, hFc Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for IFN alpha/beta R1[Biotin], His & Avi, Human, His-Avi Tag with the EC50 of 2.8 ng/ml determined by ELISA.

IFN Alpha/beta R1[Biotin], His & Avi, Human

The purity of IFN alpha/beta R1[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

IFN Alpha/beta R1[Biotin], His & Avi, Human

IFN alpha/beta R1[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

IFN alpha/beta R1[Biotin], His & Avi, Human

IFN-alpha / beta R1, also known as IFNAR1, belongs to the class II cytokine receptor family of proteins. Class II cytokine receptors form heterodimeric receptor complexes that mediate class II cytokine signals. Subunits of the different receptor complexes are shared and serve multiple functions.Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves.
Z04480
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Product Introduction
Species Human
Protein Construction
IFN alpha/beta R1 (Lys28-Lys436)
Accession # P17181-1		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Anti­IFNAR1 Antibody, hFc Tag at 1μg/ml (100μl/well) on the plate can bind IFN alpha/beta R1[Biotin], His & Avi, Human. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 50.2 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 75-100 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • IFN Alpha/beta R1[Biotin], His & Avi, Human
    • IFN Alpha/beta R1[Biotin], His & Avi, Human

    Immobilized Anti-IFN-alpha R1 Antibody, hFc Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for IFN alpha/beta R1[Biotin], His & Avi, Human, His-Avi Tag with the EC50 of 2.8 ng/ml determined by ELISA.

  • IFN Alpha/beta R1[Biotin], His & Avi, Human
    • IFN Alpha/beta R1[Biotin], His & Avi, Human

    The purity of IFN alpha/beta R1[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • IFN Alpha/beta R1[Biotin], His & Avi, Human
    • IFN Alpha/beta R1[Biotin], His & Avi, Human

    IFN alpha/beta R1[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.


Background
Target Background IFN-alpha / beta R1, also known as IFNAR1, belongs to the class II cytokine receptor family of proteins. Class II cytokine receptors form heterodimeric receptor complexes that mediate class II cytokine signals. Subunits of the different receptor complexes are shared and serve multiple functions.Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves.
Synonyms AVP; IFN-alpha/beta R1; IFN-alpha-REC; IFNAR; IFNAR1; IFN-aR1; IFNBR; IFNbR1; IFN-R-1; CRF2-1; IFRC ; IFN-alpha/β R1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.