GDF15[Biotin], His & Avi, Human
GDF15[Biotin], His & Avi, Human

Immobilized Human GFRAL, hFc Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for GDF15[Biotin], His & Avi, Human, His Tag with the EC50 of 29.9 ng/ml determined by ELISA.

GDF15[Biotin], His & Avi, Human

GDF15[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced (R) condition and Non reducing (N) condition. The purity is greater than 95%.

GDF15[Biotin], His & Avi, Human

Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15.
Z04469
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Product Introduction
Species Human
Protein Construction
Avi His GDF15 (Ala197-Ile308)
Accession # Q99988-1
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1 EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Human GFRAL, hFc Tag at 5μg/ml (100 μl/Well) on the plate can bind GDF15[Biotin], His & Avi, Human. Test result was comparable to standard batch.
Expression System E.coli
Theoretical Molecular Weight 15.19 kDa
Apparent Molecular Weight The protein has a predicted MW of 15.19 kDa same as Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in 50 mM HAc (pH 2.9).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in 50 mM HAc (pH 2.9).
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • GDF15[Biotin], His & Avi, Human
    • GDF15[Biotin], His & Avi, Human

    Immobilized Human GFRAL, hFc Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for GDF15[Biotin], His & Avi, Human, His Tag with the EC50 of 29.9 ng/ml determined by ELISA.

  • GDF15[Biotin], His & Avi, Human
    • GDF15[Biotin], His & Avi, Human

    GDF15[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced (R) condition and Non reducing (N) condition. The purity is greater than 95%.


Background
Target Background Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15.
Synonyms GDF-15; MIC-1; NAG-1; PDF; PLAB; PTGFB; GDF15; MIC1; RG-1; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta; Placental TGF-β; PTGF-β; PTGFBPTGF-β

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.