FcRn[Biotin], His & Avi, Human
FcRn[Biotin], His & Avi, Human

The purity of FcRn[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

FcRn[Biotin], His & Avi, Human

FcRn[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

FcRn[Biotin], His & Avi, Human

FcRn[Biotin], His & Avi, Human, His Tag captured on CM5 Chip via anti-his antibody can bind Trastuzumab with an affinity constant of 0.557 uM asdetermined in SPR assay (Biacore T200).

FcRn[Biotin], His & Avi, Human

The neonatal Fc receptor (FCRN) is an approximately 45 kDa transmembrane glycoprotein with structural homology to MHC class I proteins. It is widely expressed in endothelial and epithelial cells and plays an important role in IgG homeostasis and antigen presentation by dendritic cells.FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51, and p14 , and forms an MHC class I-like heterodimer.
Z04456
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Product Introduction
Species Human
Protein Construction
FcRn (Ala24-Ser297 (FCGRT) & Ile21-Met119 (B2M))
Accession # P55899 (FCGRT) & P61769 ((B2M)		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity FcRn[Biotin], His & Avi, Human captured on CM5 Chip via anti­his antibody can bind Trastuzumab in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 46.5 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 48-55 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • FcRn[Biotin], His & Avi, Human
    • FcRn[Biotin], His & Avi, Human

    The purity of FcRn[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • FcRn[Biotin], His & Avi, Human
    • FcRn[Biotin], His & Avi, Human

    FcRn[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • FcRn[Biotin], His & Avi, Human
    • FcRn[Biotin], His & Avi, Human

    FcRn[Biotin], His & Avi, Human, His Tag captured on CM5 Chip via anti-his antibody can bind Trastuzumab with an affinity constant of 0.557 uM asdetermined in SPR assay (Biacore T200).


Background
Target Background The neonatal Fc receptor (FCRN) is an approximately 45 kDa transmembrane glycoprotein with structural homology to MHC class I proteins. It is widely expressed in endothelial and epithelial cells and plays an important role in IgG homeostasis and antigen presentation by dendritic cells.FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51, and p14 , and forms an MHC class I-like heterodimer.
Synonyms FcRn alpha chain; FCGRT; FCRN; FCGRT&B2M

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.