Fc gamma RIIIB/CD16b (NA2)[Biotin], His & Avi, Human
Fc Gamma RIIIB/CD16b (NA2)[Biotin], His & Avi, Human

The purity of Fc gamma RIIIB/CD16b (NA2)[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

Fc Gamma RIIIB/CD16b (NA2)[Biotin], His & Avi, Human

Fc gamma RIIIB/CD16b (NA2)[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Fc Gamma RIIIB/CD16b (NA2)[Biotin], His & Avi, Human

Fc gamma RIIIB/CD16b (NA2)[Biotin], His & Avi, Human, His Tag captured on CM5 Chip via Anti-his antibody can bind Rituximab with an affinity constant of 3.50 μM as determined in SPR assay (Biacore T200).

Fc gamma RIIIB/CD16b (NA2)[Biotin], His & Avi, Human

Human Fc gamma RIIIB/CD16b Protein is a receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
Z04453
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Product Introduction
Species Human
Protein Construction
Fc gamma RIIIB/CD16b (NA2)[Gly17-Ser200 (NA2)]
Accession # O75015-1		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Fc gamma RIIIB/CD16b (NA2)[Biotin], His & Avi, Human captured on CM5 Chip via Anti­His Antibody can bind Rituximab in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 23.7 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 47-53 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • Fc Gamma RIIIB/CD16b (NA2)[Biotin], His & Avi, Human
    • Fc Gamma RIIIB/CD16b (NA2)[Biotin], His & Avi, Human

    The purity of Fc gamma RIIIB/CD16b (NA2)[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • Fc Gamma RIIIB/CD16b (NA2)[Biotin], His & Avi, Human
    • Fc Gamma RIIIB/CD16b (NA2)[Biotin], His & Avi, Human

    Fc gamma RIIIB/CD16b (NA2)[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • Fc Gamma RIIIB/CD16b (NA2)[Biotin], His & Avi, Human
    • Fc Gamma RIIIB/CD16b (NA2)[Biotin], His & Avi, Human

    Fc gamma RIIIB/CD16b (NA2)[Biotin], His & Avi, Human, His Tag captured on CM5 Chip via Anti-his antibody can bind Rituximab with an affinity constant of 3.50 μM as determined in SPR assay (Biacore T200).


Background
Target Background Human Fc gamma RIIIB/CD16b Protein is a receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
Synonyms CD16; Fc gamma RIIIB; FCG3; FCGR3B; FcgRIIIB; FCRIIIB; IGFR3; CD16b (NA2); CD16B; FCG3B; FCG3; FCGR3; FCR-10

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.