DNAM-1/CD226[Biotin], His & Avi, Human

DNAM-1/CD226[Biotin], His & Avi, Human

DNAX accessory molecule-1 (DNAM-1), also known as CD226, is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily.DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2.
Z04442
¥123,118.00

Ask us a question
Product Introduction
Species Human
Protein Construction
DNAM-1/CD226 (Glu19--Asn247)
Accession # Q15762		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by SEC­HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized DNAM-1/CD226[Biotin], His & Avi, Human at 1μg/ml (100μl/well) on the streptavidin precoated plate(5μg/ml) can bind Human CD155, mFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 28.9 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background DNAX accessory molecule-1 (DNAM-1), also known as CD226, is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily.DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2.
Synonyms CD226 molecule; CD226; DNAM1; PTA1; TLiSA1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.