B7-H2/ICOSLG[Biotin], His & Avi, Human
B7-H2/ICOSLG[Biotin], His & Avi, Human

Immobilized Human ICOS (C136S, C137S), His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for B7-H2/ICOSLG[Biotin], His & Avi, Human, His Tag with the EC50 of 25.1 ng/ml determined by ELISA.

B7-H2/ICOSLG[Biotin], His & Avi, Human

B7-H2/ICOSLG[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

B7-H2/ICOSLG[Biotin], His & Avi, Human

B7-H2, also known as B7-related protein (B7RP1), ICOS Ligand, and CD275, is an approximately 60 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells.
Z04408
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Product Introduction
Species Human
Protein Construction
B7-H2/ICOSLG (Asp19-Ser258)
Accession # O75144		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Human ICOS (C136S,C137S), His Tag at 2μg/ml (100μl/Well) on the plate can bind B7-H2/ICOSLG[Biotin], His & Avi, Human. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 29.5 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 55-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • B7-H2/ICOSLG[Biotin], His & Avi, Human
    • B7-H2/ICOSLG[Biotin], His & Avi, Human

    Immobilized Human ICOS (C136S, C137S), His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for B7-H2/ICOSLG[Biotin], His & Avi, Human, His Tag with the EC50 of 25.1 ng/ml determined by ELISA.

  • B7-H2/ICOSLG[Biotin], His & Avi, Human
    • B7-H2/ICOSLG[Biotin], His & Avi, Human

    B7-H2/ICOSLG[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background B7-H2, also known as B7-related protein (B7RP1), ICOS Ligand, and CD275, is an approximately 60 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells.
Synonyms CD275; B7H2; B7-H2; B7RP-1; GL50; ICOSL; ICOS-L; ICOSLG; B7RP1; LICOS; ICOS ligand; B7-H2B7-related protein 1; B7RP-1; B7RP1B7-like protein Gl50

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.