ALCAM/CD166 [Biotin], His, Human
ALCAM/CD166 [Biotin], His, Human

Immobilized Anti-ALCAM Antibody, hFc Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for ALCAM/CD166 [Biotin], His, Human, His Tag with the EC50 of 2.62 μg/ml determined by ELISA.

ALCAM/CD166 [Biotin], His, Human

ALCAM/CD166 [Biotin], His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

ALCAM/CD166 [Biotin], His, Human

Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis.Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the brain endothelial cells. Therefore, ALCAM could be targeted to reduce the occurrence of BM.
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Product Introduction
Species Human
Protein Construction
ALCAM/CD166 (Trp28-Ala526)
Accession # Q13740-1		 His
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per ug by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Anti­ALCAM Antibody, hFc Tag at 5μg/ml (100μl/well) on the plate can bind ALCAM/CD166 [Biotin], His, Human. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 57 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • ALCAM/CD166 [Biotin], His, Human
    • ALCAM/CD166 [Biotin], His, Human

    Immobilized Anti-ALCAM Antibody, hFc Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for ALCAM/CD166 [Biotin], His, Human, His Tag with the EC50 of 2.62 μg/ml determined by ELISA.

  • ALCAM/CD166 [Biotin], His, Human
    • ALCAM/CD166 [Biotin], His, Human

    ALCAM/CD166 [Biotin], His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis.Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the brain endothelial cells. Therefore, ALCAM could be targeted to reduce the occurrence of BM.
Synonyms CD166; ALCAM; MEMD; CD6L; KG-CAM

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.