4-1BB/TNFRSF9 hFc Chimera[Biotin], Avi, Human
4-1BB/TNFRSF9 HFc Chimera[Biotin], Avi, Human

Immobilized 4-1BB/TNFRSF9 hFc Chimera[Biotin], Avi, Human, hFc Tag at 1 μg/ml (100 μl/Well) on streptavidin(5 μg/ml) precoated plate. Dose response curve for Human IL-17R alpha, His Tag with the EC50 of 14.5 ng/ml determined by ELISA.

4-1BB/TNFRSF9 HFc Chimera[Biotin], Avi, Human

The purity of 4-1BB/TNFRSF9 hFc Chimera[Biotin], Avi, Human is greater than 95% as determined by SEC-HPLC.

4-1BB/TNFRSF9 HFc Chimera[Biotin], Avi, Human

4-1BB/TNFRSF9 hFc Chimera[Biotin], Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

4-1BB/TNFRSF9 hFc Chimera[Biotin], Avi, Human

4-1BB, is also known as CD137, is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily.CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, B cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation.
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Product Introduction
Species Human
Protein Construction
4-1BB/TNFRSF9 (Leu24-Gln186)
Accession # Q07011		 hFc Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 45.7 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • 4-1BB/TNFRSF9 HFc Chimera[Biotin], Avi, Human
    • 4-1BB/TNFRSF9 HFc Chimera[Biotin], Avi, Human

    Immobilized 4-1BB/TNFRSF9 hFc Chimera[Biotin], Avi, Human, hFc Tag at 1 μg/ml (100 μl/Well) on streptavidin(5 μg/ml) precoated plate. Dose response curve for Human IL-17R alpha, His Tag with the EC50 of 14.5 ng/ml determined by ELISA.

  • 4-1BB/TNFRSF9 HFc Chimera[Biotin], Avi, Human
    • 4-1BB/TNFRSF9 HFc Chimera[Biotin], Avi, Human

    The purity of 4-1BB/TNFRSF9 hFc Chimera[Biotin], Avi, Human is greater than 95% as determined by SEC-HPLC.

  • 4-1BB/TNFRSF9 HFc Chimera[Biotin], Avi, Human
    • 4-1BB/TNFRSF9 HFc Chimera[Biotin], Avi, Human

    4-1BB/TNFRSF9 hFc Chimera[Biotin], Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background 4-1BB, is also known as CD137, is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily.CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, B cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation.
Synonyms CD137; TNFRSF9; 4-1BB ligand receptor; 41BB; 4-1BB; CDw137; FLJ43501; ILA; T cell antigen ILA

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.