LRRC15/LIB[Biotin], His & Avi, Cynomolgus/Rhesus macaque

LRRC15/LIB[Biotin], His & Avi, Cynomolgus/Rhesus macaque

The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation. LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge of migrating cells, the expression of which in normal tissues is restricted to the invasive cytotrophoblast layer of the placenta; small interfering (siRNA)-mediated suppression of LRRC15 expression in breast cancer cells leads to abrogation of invasiveness in vitro.
Z04380
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Product Introduction
Species Cynomolgus/Rhesus macaque
Protein Construction
LRRC15/LIB (Tyr22-Gly538)
Accession # A0A2K5UKB6 (Cynomolgus) / F7FSB9 (Rhesus macaque)		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
> 95%  as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Anti­LRRC15 Antibody, hFc Tag at 5μg/ml (100μl/well) on the plate can bind LRRC15/LIB[Biotin], His & Avi, Cynomolgus/Rhesus macaque. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 61.50 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-90 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation. LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge of migrating cells, the expression of which in normal tissues is restricted to the invasive cytotrophoblast layer of the placenta; small interfering (siRNA)-mediated suppression of LRRC15 expression in breast cancer cells leads to abrogation of invasiveness in vitro.
Synonyms LIB; LRRC15; EGM_11224

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.