IFN alpha/beta R1[Biotin], His & Avi, Cynomolgus
IFN Alpha/beta R1[Biotin], His & Avi, Cynomolgus

The purity of IFN alpha/beta R1[Biotin], His & Avi, Cynomolgus is greater than 95% as determined by SEC-HPLC.

IFN Alpha/beta R1[Biotin], His & Avi, Cynomolgus

IFN alpha/beta R1[Biotin], His & Avi, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IFN Alpha/beta R1[Biotin], His & Avi, Cynomolgus

IFN alpha/beta R1[Biotin], His & Avi, Cynomolgus, His-Avi Tag captured on CM5 Chip via Streptavidin can bind Human IFN alpha 1, hFc Tag with an affinity constant of 1.16 nM as determined in SPR assay (Biacore T200).

IFN alpha/beta R1[Biotin], His & Avi, Cynomolgus

IFN-alpha / beta R1, also known as IFNAR1, belongs to the class II cytokine receptor family of proteins. Class II cytokine receptors form heterodimeric receptor complexes that mediate class II cytokine signals. Subunits of the different receptor complexes are shared and serve multiple functions.Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves
Z04368
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Product Introduction
Species Cynomolgus
Protein Construction
IFN alpha/beta R1 (Ala25-Lys437)
Accession # A0A7N9D7J0		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE
> 95%  as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity IFN alpha/beta R1[Biotin], His & Avi, Cynomolgus captured on CM5 Chip via Anti­His Antibody can bind Human IFN alpha 1, hFc Tag in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 50.35 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 75-105 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • IFN Alpha/beta R1[Biotin], His & Avi, Cynomolgus
    • IFN Alpha/beta R1[Biotin], His & Avi, Cynomolgus

    The purity of IFN alpha/beta R1[Biotin], His & Avi, Cynomolgus is greater than 95% as determined by SEC-HPLC.

  • IFN Alpha/beta R1[Biotin], His & Avi, Cynomolgus
    • IFN Alpha/beta R1[Biotin], His & Avi, Cynomolgus

    IFN alpha/beta R1[Biotin], His & Avi, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • IFN Alpha/beta R1[Biotin], His & Avi, Cynomolgus
    • IFN Alpha/beta R1[Biotin], His & Avi, Cynomolgus

    IFN alpha/beta R1[Biotin], His & Avi, Cynomolgus, His-Avi Tag captured on CM5 Chip via Streptavidin can bind Human IFN alpha 1, hFc Tag with an affinity constant of 1.16 nM as determined in SPR assay (Biacore T200).


Background
Target Background IFN-alpha / beta R1, also known as IFNAR1, belongs to the class II cytokine receptor family of proteins. Class II cytokine receptors form heterodimeric receptor complexes that mediate class II cytokine signals. Subunits of the different receptor complexes are shared and serve multiple functions.Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves
Synonyms AVP; IFN-alpha/beta R1; IFN-alpha-REC; IFNAR; IFNAR1; IFN-aR1; IFNBR; IFNbR1; IFN-R-1; CRF2-1; IFRC ; IFN-alpha/β R1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.