FcRn, His, Rat
FcRn, His, Rat

The purity of FcRn, His, Rat is greater than 95% as determined by SEC-HPLC.

FcRn, His, Rat

FcRn, His, Rat on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

FcRn, His, Rat

FcRn, His, Rat, His Tag captured on CM5 Chip via Anti-His Antibody can bind Trastuzumab with an affinity constant of 3.26 nM as determined in SPR assay (Biacore T200).

FcRn, His, Rat

The neonatal Fc receptor (FCRN) is an approximately 45 kDa transmembrane glycoprotein with structural homology to MHC class I proteins. It is widely expressed in endothelial and epithelial cells and plays an important role in IgG homeostasis and antigen presentation by dendritic cells.FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51, and p14 , and forms an MHC class I-like heterodimer.
Z04354
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Product Introduction
Species Rat
Protein Construction
FcRn [Ala23-Ser298 (FCGRT) and Ile21-Met119 (B2M)]
Accession # P13599 (FCGRT) & P07151 (B2M)		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 32.60 kDa (FCGRT) and 11.63 kDa (B2M)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 45-60 kDa (FCGRT) and 13-15 kDa (B2M) based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • FcRn, His, Rat
    • FcRn, His, Rat

    The purity of FcRn, His, Rat is greater than 95% as determined by SEC-HPLC.

  • FcRn, His, Rat
    • FcRn, His, Rat

    FcRn, His, Rat on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • FcRn, His, Rat
    • FcRn, His, Rat

    FcRn, His, Rat, His Tag captured on CM5 Chip via Anti-His Antibody can bind Trastuzumab with an affinity constant of 3.26 nM as determined in SPR assay (Biacore T200).


Background
Target Background The neonatal Fc receptor (FCRN) is an approximately 45 kDa transmembrane glycoprotein with structural homology to MHC class I proteins. It is widely expressed in endothelial and epithelial cells and plays an important role in IgG homeostasis and antigen presentation by dendritic cells.FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51, and p14 , and forms an MHC class I-like heterodimer.
Synonyms FcRn alpha chain; FCGRT; FCRN; FCGRT&B2M

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.