FGFR4 hFc Chimera, Human
FGFR4 HFc Chimera, Human

The purity of FGFR4 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

FGFR4 HFc Chimera, Human

FGFR4 hFc Chimera, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

FGFR4 HFc Chimera, Human

FGFR4 hFc Chimera, Human, hFc Tag captured on CM5 Chip via Protein A can bind Human Beta Klotho, His Tag with an affinity constant of 13.05 nM as determined in SPR assay (Biacore T200).

FGFR4 hFc Chimera, Human

Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19.
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Product Introduction
Species Human
Protein Construction
FGFR4 (Leu22-Asp369)
Accession # P22455		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity FGFR4 hFc Chimera, Human captured on CM5 Chip via Protein A can bind Human Beta Klotho, His Tag in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 65.3 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 80-95 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • FGFR4 HFc Chimera, Human
    • FGFR4 HFc Chimera, Human

    The purity of FGFR4 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

  • FGFR4 HFc Chimera, Human
    • FGFR4 HFc Chimera, Human

    FGFR4 hFc Chimera, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

  • FGFR4 HFc Chimera, Human
    • FGFR4 HFc Chimera, Human

    FGFR4 hFc Chimera, Human, hFc Tag captured on CM5 Chip via Protein A can bind Human Beta Klotho, His Tag with an affinity constant of 13.05 nM as determined in SPR assay (Biacore T200).


Background
Target Background Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19.
Synonyms CD334; FGF R4; FGFR4; FGFR-4; MGC20292; JTK2; TKF

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.