CD27/TNFRSF7 hFc Chimera, Human
CD27/TNFRSF7 HFc Chimera, Human

Immobilized Human CD27 Ligand (Trimer), His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for CD27/TNFRSF7 hFc Chimera, Human, hFc Tag with the EC50 of 15.7 ng/ml determined by ELISA.

CD27/TNFRSF7 HFc Chimera, Human

The purity of CD27/TNFRSF7 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

CD27/TNFRSF7 HFc Chimera, Human

CD27/TNFRSF7 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

CD27/TNFRSF7 hFc Chimera, Human

CD27, also known as TNFRSF7, is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily. It functions as a co‑stimulatory molecule that supports lymphocyte activation and survival. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis.
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Product Introduction
Species Human
Protein Construction
CD27/TNFRSF7 (Thr21-Ile192)
Accession # P26842		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Human CD27 Ligand Trimer, His Tag at 2μg/ml (100μl/Well) on the plate can bind CD27/TNFRSF7 hFc Chimera, Human. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 46.2 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-75 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • CD27/TNFRSF7 HFc Chimera, Human
    • CD27/TNFRSF7 HFc Chimera, Human

    Immobilized Human CD27 Ligand (Trimer), His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for CD27/TNFRSF7 hFc Chimera, Human, hFc Tag with the EC50 of 15.7 ng/ml determined by ELISA.

  • CD27/TNFRSF7 HFc Chimera, Human
    • CD27/TNFRSF7 HFc Chimera, Human

    The purity of CD27/TNFRSF7 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

  • CD27/TNFRSF7 HFc Chimera, Human
    • CD27/TNFRSF7 HFc Chimera, Human

    CD27/TNFRSF7 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background CD27, also known as TNFRSF7, is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily. It functions as a co‑stimulatory molecule that supports lymphocyte activation and survival. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis.
Synonyms CD27 antigen; Tp55; TNFRSF7; S152; T14; S152. LPFS2; MGC20393; S152CD27L receptor

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.