CD200 R1/CRTR2, His, Cynomolgus

CD200 R1/CRTR2, His, Cynomolgus

CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid and T cell lineage. A recent report focused attention on a family of CD200Rs, but concluded that only one member used CD200 as its ligand.
Z04108
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Product Introduction
Species Cynomolgus
Protein Construction
CD200 R1/CRTR2 (Glu25-Leu267)
Accession # XP_005548207.1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized CD200 R1/CRTR2, His, Cynomolgus at 1μg/ml (100μl/well) on the plate can bind Human CD200, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 28.09 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 67-77 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid and T cell lineage. A recent report focused attention on a family of CD200Rs, but concluded that only one member used CD200 as its ligand.
Synonyms CD200R; CRTR2; MOX2R; OX2R; CD200 R1; CD200 receptor 1; HCRTR2; MOX2 receptor

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.