Siglec-2/CD22[Biotin], His & Avi, Human
Siglec-2/CD22[Biotin], His & Avi, Human

Immobilized Siglec-2/CD22[Biotin], His & Avi, Human, His Tag at 1 μg/ml(100 μL/well) on the streptavidin precoated plate(5 μg/ml). Dose response curve for Anti-Siglec-2 Antibody, hFc Tag with the EC50 of 9.0 ng/ml determined by ELISA.

Siglec-2/CD22[Biotin], His & Avi, Human

The purity of Siglec-2/CD22[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

Siglec-2/CD22[Biotin], His & Avi, Human

Siglec-2/CD22[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Siglec-2/CD22[Biotin], His & Avi, Human

CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.
Z04100
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Product Introduction
Species Human
Protein Construction
Siglec-2/CD22 (Asp20-Arg687)
Accession # P20273-1		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Siglec-2/CD22[Biotin], His & Avi, Human at 1μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml) can bind Anti-Siglec-2 Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 78.1 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 110-120 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • Siglec-2/CD22[Biotin], His & Avi, Human
    • Siglec-2/CD22[Biotin], His & Avi, Human

    Immobilized Siglec-2/CD22[Biotin], His & Avi, Human, His Tag at 1 μg/ml(100 μL/well) on the streptavidin precoated plate(5 μg/ml). Dose response curve for Anti-Siglec-2 Antibody, hFc Tag with the EC50 of 9.0 ng/ml determined by ELISA.

  • Siglec-2/CD22[Biotin], His & Avi, Human
    • Siglec-2/CD22[Biotin], His & Avi, Human

    The purity of Siglec-2/CD22[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • Siglec-2/CD22[Biotin], His & Avi, Human
    • Siglec-2/CD22[Biotin], His & Avi, Human

    Siglec-2/CD22[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.
Synonyms CD22 molecule; CD22; Siglec-2; B-cell receptor CD22; BL-CAM; SIGLEC2; SIGLEC2FLJ22814

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.