FGFR1 alpha (IIIc)[Biotin], His & Avi, Human
FGFR1 Alpha (IIIc)[Biotin], His & Avi, Human

Immobilized FGFR1 alpha (IIIc)[Biotin], His & Avi, Human, His Tag at 1 μg/ml (100 μl/Well) on streptavidin(5 μg/ml) precoated plate. Dose response curve for Anti-FGFR1 Anitibody, hFc Tag with the EC50 of 9.2ng/ml determined by ELISA.

FGFR1 Alpha (IIIc)[Biotin], His & Avi, Human

The purity of FGFR1 alpha (IIIc)[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

FGFR1 Alpha (IIIc)[Biotin], His & Avi, Human

FGFR1 alpha (IIIc)[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

FGFR1 alpha (IIIc)[Biotin], His & Avi, Human

Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding.FGFR1 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.
Z04083
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Product Introduction
Species Human
Protein Construction
FGFR1 alpha (IIIc) (Arg22-Glu374)
Accession # P11362-7		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 42 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 68-80 kDa based on Tris-BisPAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • FGFR1 Alpha (IIIc)[Biotin], His & Avi, Human
    • FGFR1 Alpha (IIIc)[Biotin], His & Avi, Human

    Immobilized FGFR1 alpha (IIIc)[Biotin], His & Avi, Human, His Tag at 1 μg/ml (100 μl/Well) on streptavidin(5 μg/ml) precoated plate. Dose response curve for Anti-FGFR1 Anitibody, hFc Tag with the EC50 of 9.2ng/ml determined by ELISA.

  • FGFR1 Alpha (IIIc)[Biotin], His & Avi, Human
    • FGFR1 Alpha (IIIc)[Biotin], His & Avi, Human

    The purity of FGFR1 alpha (IIIc)[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • FGFR1 Alpha (IIIc)[Biotin], His & Avi, Human
    • FGFR1 Alpha (IIIc)[Biotin], His & Avi, Human

    FGFR1 alpha (IIIc)[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding.FGFR1 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.
Synonyms FGF R1a; FGFR1 alpha

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.