DLL4 hFc Chimera, Human
DLL4 HFc Chimera, Human

Immobilized DLL4 hFc Chimera, Human at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-DLL4 Antibody, hFc Tag with the EC50 of 24.3 ng/ml determined by ELISA.

DLL4 HFc Chimera, Human

DLL4 hFc Chimera, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

DLL4 HFc Chimera, Human

DLL4 hFc Chimera, Human captured on CM5 Chip via Protein A can bind Human Notch 1, His Tag with an affinity constant of 0.48 μM as determined in SPR assay (Biacore T200).

DLL4 HFc Chimera, Human

The purity of  DLL4 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

DLL4 hFc Chimera, Human

Delta-like protein 4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate.
Z03955
¥48,501.00

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Product Introduction
Species Human
Protein Construction
DLL4 (Ser27-Pro524)
Accession # Q9NR61		 hFc
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Immobilized DLL4 hFc Chimera, Human (Cat.No.: Z03955) at 1 μg/ml (100μl/Well) on the plate can bind Biotinylated Anti-DLL4 Antibody, hFc Tag
Expression System HEK293
Theoretical Molecular Weight 81.1 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 82-90 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, (pH 7.4).
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O more than 100 μg/ml.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • DLL4 HFc Chimera, Human
    • DLL4 HFc Chimera, Human

    Immobilized DLL4 hFc Chimera, Human at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-DLL4 Antibody, hFc Tag with the EC50 of 24.3 ng/ml determined by ELISA.

  • DLL4 HFc Chimera, Human
    • DLL4 HFc Chimera, Human

    DLL4 hFc Chimera, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

  • DLL4 HFc Chimera, Human
    • DLL4 HFc Chimera, Human

    DLL4 hFc Chimera, Human captured on CM5 Chip via Protein A can bind Human Notch 1, His Tag with an affinity constant of 0.48 μM as determined in SPR assay (Biacore T200).

  • DLL4 HFc Chimera, Human
    • DLL4 HFc Chimera, Human

    The purity of  DLL4 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.


Background
Target Background Delta-like protein 4 (DLL4) is a type I transmembrane protein with a DSL domain and eight tandem EGF repeats. DLL4 functions as a Notch ligand and activates NOTCH1 and NOTCH4 in the Notch signaling pathway. It is involved in vascular development and homeostasis. DLL4 is involved in vascular development and homeostasis. It is highly expressed in some cancers, such as bladder, breast cancers.
Synonyms DLL4; MGC126344; notch ligand DLL4; Delta4; Delta-like 4

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.