DLL3 Domain (311-479), His&Avi, Human
DLL3 Domain (311-479), His&Avi, Human

Immobilized DLL3 Domain (311-479), His & Avi, Human at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-DLL3 Antibody, hFc Tag with the EC50 of 2.9 ng/ml determined by ELISA.

DLL3 Domain (311-479), His&Avi, Human

DLL3 Domain (311-479), His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

DLL3 Domain (311-479), His&Avi, Human

The purity of DLL3 Domain (311-479), His & Avi, Human is greater than 95% as determined by SEC-HPLC.

DLL3 Domain (311-479), His&Avi, Human

Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).
Z03951
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Product Introduction
Species Human
Protein Construction
DLL3 Domain (Val311-Ala479)
Accession # Q9NYJ7-1		 His Avi
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Immobilized DLL3 Domain (311-479), His&Avi, Human (Cat.No.: Z03951) at 1 μg/ml (100μl/Well) on the plate can bind Anti-DLL3 Antibody, hFc Tag
Expression System HEK293
Theoretical Molecular Weight 21.20 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 25-30 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, (pH 7.4).
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O more than 100 μg/ml.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • DLL3 Domain (311-479), His&Avi, Human
    • DLL3 Domain (311-479), His&Avi, Human

    Immobilized DLL3 Domain (311-479), His & Avi, Human at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-DLL3 Antibody, hFc Tag with the EC50 of 2.9 ng/ml determined by ELISA.

  • DLL3 Domain (311-479), His&Avi, Human
    • DLL3 Domain (311-479), His&Avi, Human

    DLL3 Domain (311-479), His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • DLL3 Domain (311-479), His&Avi, Human
    • DLL3 Domain (311-479), His&Avi, Human

    The purity of DLL3 Domain (311-479), His & Avi, Human is greater than 95% as determined by SEC-HPLC.


Background
Target Background Delta-like ligand 3 (DLL3) is an inhibitory Notch ligand. It is highly expressed on the surface of Small cell lung cancer (SCLC) and other neuroendocrine tumors. And its expression promotes SCLC migration and invasion. DLL3 agents are evaluated in several ongoing clinical studies in SCLC and other neuroendocrine tumors.
Synonyms Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.