FOLR1 hFc Chimera, Human
FOLR1 HFc Chimera, Human

Immobilized FOLR1 hFc Chimera, Human at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-FOLR1 Antibody, hFc Tag with the EC50 of 27.4 ng/ml determined by ELISA.

FOLR1 HFc Chimera, Human

FOLR1 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

FOLR1 HFc Chimera, Human

The purity of FOLR1 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

FOLR1 hFc Chimera, Human

Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH.
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Product Introduction
Species Human
Protein Construction
FOLR1 (Arg25-Met233)
Accession # P15328		 hFc
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 51.3 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, pH 7.4 .
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O more than 100 μg/ml.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • FOLR1 HFc Chimera, Human
    • FOLR1 HFc Chimera, Human

    Immobilized FOLR1 hFc Chimera, Human at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-FOLR1 Antibody, hFc Tag with the EC50 of 27.4 ng/ml determined by ELISA.

  • FOLR1 HFc Chimera, Human
    • FOLR1 HFc Chimera, Human

    FOLR1 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • FOLR1 HFc Chimera, Human
    • FOLR1 HFc Chimera, Human

    The purity of FOLR1 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.


Background
Target Background Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH.
Synonyms FR-alpha; FR alpha; FR α; FOLR; FOLR1; FBP; Folbp1; KB cells FBP; MOv18; Folate receptor 1; Fbp1; Folate receptor alpha;

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.