Her2/ErbB2, His, Mouse
Her2/ErbB2, His, Mouse

Her2/ErbB2, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Her2/ErbB2, His, Mouse

The purity of Her2/ErbB2, His, Mouse is greater than 95% as determined by SEC-HPLC.

Her2/ErbB2, His, Mouse

Immobilized Her2/ErbB2, His, Mouse at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-HER2 Antibody, Rabbit Fc Tag with the EC50 of 33.3 ng/ml determined by ELISA.

Her2/ErbB2, His, Mouse

ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors.Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane.
Z03904
¥67,155.00

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Product Introduction
Species Mouse
Protein Construction
His Her2/ErbB2 (Thr23-Thr653)
Accession # P70424
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Immobilized Her2/ErbB2, His, Mouse (Cat.No.: Z03904) at 0.5 μg/ml (100μl/Well) on the plate can bind Anti-HER2 Antibody, Rabbit Fc Tag
Expression System HEK293
Theoretical Molecular Weight 70.74 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 80-100 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, pH 7.4.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O more than 100 μg/ml.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • Her2/ErbB2, His, Mouse
    • Her2/ErbB2, His, Mouse

    Her2/ErbB2, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • Her2/ErbB2, His, Mouse
    • Her2/ErbB2, His, Mouse

    The purity of Her2/ErbB2, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • Her2/ErbB2, His, Mouse
    • Her2/ErbB2, His, Mouse

    Immobilized Her2/ErbB2, His, Mouse at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-HER2 Antibody, Rabbit Fc Tag with the EC50 of 33.3 ng/ml determined by ELISA.


Background
Target Background ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors.Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane.
Synonyms CD340; EGFR2; ErbB2; HER2; HER-2; herstatin; MLN 19; MLN19; NGL; TKR1; ERBB2; NEU; ENV; ENVW; ERVWE1; HERV7Q; HERVW

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.