MSLN/Mesothelin(298-600), His, Rat
MSLN/Mesothelin(298-600), His, Rat

Immobilized MSLN/Mesothelin(298-600), His, Rat, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Human CA125, His Tag with the EC50 of 17.9 ng/ml determined by ELISA.

MSLN/Mesothelin(298-600), His, Rat

The purity of MSLN/Mesothelin(298-600), His, Rat is greater than 95% as determined by SEC-HPLC.

MSLN/Mesothelin(298-600), His, Rat

MSLN/Mesothelin(298-600), His, Rat on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

MSLN/Mesothelin(298-600), His, Rat

Mesothelin, also known as MSLN, is a protein that in humans is encoded by the MSLN gene.Cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor (MPF).
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Product Introduction
Species Rat
Protein Construction
MSLN/Mesothelin (Asp298-Ser600)
Accession # XP_032768340.1		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 35.67 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 45-55kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, pH 7.4.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • MSLN/Mesothelin(298-600), His, Rat
    • MSLN/Mesothelin(298-600), His, Rat

    Immobilized MSLN/Mesothelin(298-600), His, Rat, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Human CA125, His Tag with the EC50 of 17.9 ng/ml determined by ELISA.

  • MSLN/Mesothelin(298-600), His, Rat
    • MSLN/Mesothelin(298-600), His, Rat

    The purity of MSLN/Mesothelin(298-600), His, Rat is greater than 95% as determined by SEC-HPLC.

  • MSLN/Mesothelin(298-600), His, Rat
    • MSLN/Mesothelin(298-600), His, Rat

    MSLN/Mesothelin(298-600), His, Rat on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Mesothelin, also known as MSLN, is encoded by the MSLN gene. It encodes a precursor protein of 71 kDa that is processed to a 31 kDa shed protein called megakaryocyte potentiating factor (MPF) and a 40 kDa fragment, mesothelin. MSLN is attached to the cell membrane by a glycosyl-phosphatidylinositol (GPI) anchor. It is a differentiation antigen which is highly expressed in several human cancers, including virtually all mesotheliomas and pancreatic adenocarcinomas.
Synonyms MSLN; CAK1 antigen; CAK1; Mesothelin; MPF; MPFSMRP; SMR

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.