MSLN/Mesothelin(298-600), His, Mouse

MSLN/Mesothelin(298-600), His, Mouse

Mesothelin, also known as MSLN, is a protein that in humans is encoded by the MSLN gene.Cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor (MPF).
Z03876
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Product Introduction
Species Mouse
Protein Construction
MSLN/Mesothelin (Asp298-Ser600)
Accession # Q61468-1		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Immobilized MSLN/Mesothelin(298-600), His, Mouse(Cat.No.: Z03876) at 2 μg/ml(100μl/Well) on the plate can bind Biotinylated Human CA125, His Tag.
Expression System HEK293
Theoretical Molecular Weight 35.2 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 35-50 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, pH 7.4.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background Mesothelin, also known as MSLN, is encoded by the MSLN gene. It encodes a precursor protein of 71 kDa that is processed to a 31 kDa shed protein called megakaryocyte potentiating factor (MPF) and a 40 kDa fragment, mesothelin. MSLN is attached to the cell membrane by a glycosyl-phosphatidylinositol (GPI) anchor. It is a differentiation antigen which is highly expressed in several human cancers, including virtually all mesotheliomas and pancreatic adenocarcinomas.
Synonyms MSLN; CAK1 antigen; CAK1; Mesothelin; MPF; MPFSMRP; SMR

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.