MSLN/Mesothelin(306-590) hFc Chimera, Cynomolgus
MSLN/Mesothelin(306-590) HFc Chimera, Cynomolgus

Immobilized MSLN/Mesothelin(306-590) hFc Chimera, Cynomolgus, hFc Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-MSLN Antibody, hFc Tag with the EC50 of 37.6 ng/ml determined by ELISA.

MSLN/Mesothelin(306-590) HFc Chimera, Cynomolgus

The purity of MSLN/Mesothelin(306-590) hFc Chimera, Cynomolgus is greater than 95% as determined by SEC-HPLC.

MSLN/Mesothelin(306-590) HFc Chimera, Cynomolgus

MSLN/Mesothelin(306-590) hFc Chimera, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

MSLN/Mesothelin(306-590) hFc Chimera, Cynomolgus

Mesothelin, also known as MSLN, is a protein that in humans is encoded by the MSLN gene.Cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor (MPF). Although it has been proposed that mesothelin may be involved in cell adhesion, its biological function is not known.A knockout mouse line that lacks mesothelin reproduces and develops normally.
Z03874
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Product Introduction
Species Cynomolgus
Protein Construction
MSLN/Mesothelin (Asp306-Gly590)
Accession # XP_065393170.1		 hFc
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Immobilized MSLN/Mesothelin(306-590) hFc Chimera, Cynomolgus (Cat.No.: Z03874) at 1 μg/ml (100μl/Well) on the plate can bind Biotinylated Anti-MSLN Antibody.
Expression System HEK293
Theoretical Molecular Weight 58.6 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, pH 7.4.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • MSLN/Mesothelin(306-590) HFc Chimera, Cynomolgus
    • MSLN/Mesothelin(306-590) HFc Chimera, Cynomolgus

    Immobilized MSLN/Mesothelin(306-590) hFc Chimera, Cynomolgus, hFc Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-MSLN Antibody, hFc Tag with the EC50 of 37.6 ng/ml determined by ELISA.

  • MSLN/Mesothelin(306-590) HFc Chimera, Cynomolgus
    • MSLN/Mesothelin(306-590) HFc Chimera, Cynomolgus

    The purity of MSLN/Mesothelin(306-590) hFc Chimera, Cynomolgus is greater than 95% as determined by SEC-HPLC.

  • MSLN/Mesothelin(306-590) HFc Chimera, Cynomolgus
    • MSLN/Mesothelin(306-590) HFc Chimera, Cynomolgus

    MSLN/Mesothelin(306-590) hFc Chimera, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Mesothelin, also known as MSLN, is encoded by the MSLN gene. It encodes a precursor protein of 71 kDa that is processed to a 31 kDa shed protein called megakaryocyte potentiating factor (MPF) and a 40 kDa fragment, mesothelin. MSLN is attached to the cell membrane by a glycosyl-phosphatidylinositol (GPI) anchor. It is a differentiation antigen which is highly expressed in several human cancers, including virtually all mesotheliomas and pancreatic adenocarcinomas.
Synonyms MSLN; CAK1; Mesothelin; MPF; MPFSMRP; SMR

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.