CEACAM-5/CD66e (323-500), His, Human

CEACAM-5/CD66e (323-500), His, Human

Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver. CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at metastatic sites. Tissues from patients with metastatic breast cancer confirmed elevated levels of CEACAM5 in lung metastases relative to breast tumors, and an inverse correlation between CEACAM5 and the mesenchymal marker vimentin was demonstrated.
Z03831
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Product Introduction
Species Human
Protein Construction
CEACAM-5/CD66e (Pro323-Leu500)
Accession # P06731-1		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 20.73 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 45-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, pH 7.4.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background CEACAM5 (Carcinoembryonic antigen-related cell adhesion molecule 5), is also known as CD66e (Cluster of Differentiation 66e). The overproduction of CEACAM5 could enrich for an epithelial gene expression pattern and facilitate tumor outgrowth at metastatic sites. CEACAM5 is often used as a synonym for many types of malignancies, such as colorectal cancer and non-small-cell lung cancer.
Synonyms CEACAM-5; CD66e; CEA; Carcinoembryonic; CEACD66e

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.