Nectin-4 IgV Domain[Biotin], His & Avi, Human

Nectin-4 IgV Domain[Biotin], His & Avi, Human

Nectin-4 seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.(Microbial infection) Acts as a receptor for measles virus.
Z03829
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Product Introduction
Species Human
Protein Construction
Nectin-4 IgV Domain (Gly32-Leu146)
Accession # Q96NY8-1		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Immobilized Nectin-4 IgV Domain[Biotin], His & Avi, Human (Cat.No.: Z03829) at 0.5 μg/ml (100μl/Well) on the plate can bind Anti-Nectin-4 Antibody.
Expression System HEK293
Theoretical Molecular Weight 15.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 16-20 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, pH 7.4.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background Nectin-4 is a tumor-associated antigen. It is probably involved in cell adhesion through trans-homophilic and -heterophilic interactions. Nectin-4 is overexpressed in urothelial carcinoma and several other malignancies. It is a promising target for antibody-drug conjugates (ADCs).
Synonyms EDSS1; LNIR; Nectin4; PRR4; NECTIN4; PVRL4

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.