Activin A, Human

Activin A, Human

Activin-A, a member of the TGF-β superfamily, has fundamental roles in embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation, and tissue fibrosis. It signals through two type I and two type II receptors, activating kinase activity, phosphorylating SMAD2 and 3 intracellular signaling mediators, forming a complex with SMAD4, and translocating to the nucleus to regulate gene expression.
Z03814
¥51,657.00

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Product Introduction
Species Human
Protein Construction
Activin A (Gly311-Ser426)
Accession # P08476
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 0.1EU per μg by the LAL method.
Biological Activity Immobilized Activin A, Human (Cat.No.: Z03814) at 1 μg/ml can bind Human Activin RIIB, His Tag. Activin A, Human (Cat.No.: Z03814) can inhibit proliferation of MPC-11 cells.
Expression System HEK293
Theoretical Molecular Weight 12.97 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 14-15 kDa under reduced (R) condition, and 23-25 kDa under Non reducing (N) condition based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in 4 mM HCI.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in 4mM HCI.
Storage & Stability Upon receiving, the lyophilized product remains stable up to 6 months at -20 °C or below as supplied from date of receipt.-80°C for 3 months after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Background
Target Background Activin-A, a member of the TGF-β superfamily, has fundamental roles in embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation, and tissue fibrosis. It signals through two type I and two type II receptors, activating kinase activity, phosphorylating SMAD2 and 3 intracellular signaling mediators, forming a complex with SMAD4, and translocating to the nucleus to regulate gene expression.
Synonyms INHBA; Activin A;

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.