DLL4, Human

DLL4, Human

DLL4 is a type I membrane protein in the Delta/Serrate/Lag2 (DSL) family of Notch ligands. It activates NOTCH1 and NOTCH4, and plays a role in angiogenesis by negatively regulating endothelial cell proliferation and migration, as well as angiogenic sprouting. It is essential for retinal progenitor proliferation and is required for suppressing rod fates in late retinal progenitors, as well as for proper generation of other retinal cell types. Additionally, during spinal cord neurogenesis, it inhibits V2a interneuron fate.
Z03812
¥46,219.00

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Product Introduction
Species Human
Protein Construction
DLL4 (Ser27-Pro524)
Accession # Q9NR61
Purity > 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Immobilized DLL4, Human (Cat.No.: Z03812) at 0.5 μg/ml can bind Anti-DLL4 Antibody.
Expression System HEK293
Theoretical Molecular Weight 54.28 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 55-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS, 200 mM Arginine, pH 7.4.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the lyophilized product remains stable up to 6 months at -20 °C or below as supplied from date of receipt.-80°C for 3 months after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Background
Target Background DLL4 is a type I membrane protein in the Delta/Serrate/Lag2 (DSL) family of Notch ligands. It activates NOTCH1 and NOTCH4, and plays a role in angiogenesis by negatively regulating endothelial cell proliferation and migration, as well as angiogenic sprouting. It is essential for retinal progenitor proliferation and is required for suppressing rod fates in late retinal progenitors, as well as for proper generation of other retinal cell types. Additionally, during spinal cord neurogenesis, it inhibits V2a interneuron fate.
Synonyms DLL4; MGC126344; notch ligand DLL4; Delta4; Delta-like 4

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.