GLP-1R mFc Chimera, Human

GLP-1R mFc Chimera, Human

The GLP1R, a GPCR, is found on pancreatic beta cells and brain neurons. It regulates blood sugar by enhancing insulin secretion. In humans, it is encoded by the gene GLP1R on chromosome 6. GLP1R is part of the glucagon receptor GPCR family and comprises an extracellular domain that binds the C-terminal helix of GLP-1 and a transmembrane domain that binds the N-terminal region of GLP-1. The TMD domain contains polar residues that regulate biased signaling, while the transmembrane helical boundaries and extracellular surface trigger biased agonism.
Z03808
¥73,407.00

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Product Introduction
Species Human
Protein Construction
GLP-1R (Arg24-Glu139)
Accession # P43220		 mFc tag
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Immobilized GLP-1R mFc Chimera, Human (Cat.No.: Z03808) at 1 μg/ml can bind Anti-GLP-1R Antibody.
Expression System HEK293
Theoretical Molecular Weight 39.20 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-65 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the lyophilized product remains stable up to 6 months at -20 °C or below as supplied from date of receipt.-80°C for 3 months after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Background
Target Background The GLP1R, a GPCR, is found on pancreatic beta cells and brain neurons. It regulates blood sugar by enhancing insulin secretion. In humans, it is encoded by the gene GLP1R on chromosome 6. GLP1R is part of the glucagon receptor GPCR family and comprises an extracellular domain that binds the C-terminal helix of GLP-1 and a transmembrane domain that binds the N-terminal region of GLP-1. The TMD domain contains polar residues that regulate biased signaling, while the transmembrane helical boundaries and extracellular surface trigger biased agonism.
Synonyms GLP1R; GLP-1-R; GLP-1R;

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.