CA125/MUC16, His & Avi, Human
CA125/MUC16, His & Avi, Human

Immobilized Human CA125, His & Avi Tag at 5 μg/ml(100 μl/Well). Dose response curve for Human MSLN with the EC50 of 3.78 μg/ml determined by ELISA.

CA125/MUC16, His & Avi, Human

Recombinant MUC16 Protein on SDS-PAGE under reducing conditions. The purity is greater than 95%.

CA125/MUC16, His & Avi, Human

The purity of Recombinant Human Muc16/CA125 Protein is greater than 95% as determined by SEC-HPLC.

CA125/MUC16, His & Avi, Human

MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN.
Z03650
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Product Introduction
Species Human
Protein Construction
CA125/MUC16 (Gly12660-Met12923)
Accession # Q8WXI7		 Poly-His Avi
N-term C-term
Purity > 95% as analyzed by SDS-PAGE
> 95% as analyzed by HPLC
Endotoxin Level ≤ 1 EU/μg of protein by LAL method
Biological Activity Immobilized Human CA125, His & Avi Tag at 5.0 μg/ml (100 μl/Well). Dose response curve for Human MSLN with the EC50 of 3.78 μg/ml determined by ELISA.
Expression System Expi293
Apparent Molecular Weight 50~80 kDa, on SDS-PAGE under reducing conditions.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, pH 7.4. Normally 5 % trehalose is added as protectant before lyophilization.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Avoid repeated freeze-thaw cycles.

Examples
  • CA125/MUC16, His & Avi, Human
    • CA125/MUC16, His & Avi, Human

    Immobilized Human CA125, His & Avi Tag at 5 μg/ml(100 μl/Well). Dose response curve for Human MSLN with the EC50 of 3.78 μg/ml determined by ELISA.

  • CA125/MUC16, His & Avi, Human
    • CA125/MUC16, His & Avi, Human

    Recombinant MUC16 Protein on SDS-PAGE under reducing conditions. The purity is greater than 95%.

  • CA125/MUC16, His & Avi, Human
    • CA125/MUC16, His & Avi, Human

    The purity of Recombinant Human Muc16/CA125 Protein is greater than 95% as determined by SEC-HPLC.


Background
Target Background MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN.
Synonyms CA125 ovarian cancer antigen; CA125; CA-125; CA125MUC-16; FLJ14303; MUC16; mucin 16, cell surface associated; mucin-16; Ovarian cancer-related tumor marker CA125; Ovarian carcinoma antigen CA125

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.