Mesothelin, hFc, Human
Mesothelin, HFc, Human

Lane 1: 2 μg of Mesothelin, hFc, Human, reducing(R)
> 95% as analyzed by SDS-PAGE

Mesothelin, hFc, Human

Mesothelin, also known as MSLN, is a 40 kDa protein that is expressed in mesothelial cells. It has been reported that this protein is over expressed in several human tumors, including mesothelioma, ovarian cancer, pancreatic adenocarcinoma, lung adenocarcinoma, and cholangiocarcinoma. Mesothelin can bind MUC16 (also known as CA125), indicating that the interaction of mesothelin and MUC16 may contribute to the implantation and peritoneal spread of tumors by cell adhesion. Since mesothelin is overexpressed in several cancers and is immunogenic, the protein could be exploited as tumor marker or as the antigenic target of a therapeutic cancer vaccine.
Z03636
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Product Introduction
Species Human
Protein Construction
Mesothelin (Glu296-Gly580)
Accession # Q13421		 hFc
N-term C-term
Purity > 90% as analyzed by SDS-PAGE
Endotoxin Level ≤ 1 EU/μg of protein by gel clotting method
Expression System HEK 293
Apparent Molecular Weight ~66 kDa, on SDS-PAGE under reducing condition.
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

Examples
  • Mesothelin, HFc, Human
    • Mesothelin, HFc, Human

    Lane 1: 2 μg of Mesothelin, hFc, Human, reducing(R)
    > 95% as analyzed by SDS-PAGE


Background
Target Background Mesothelin, also known as MSLN, is a 40 kDa protein that is expressed in mesothelial cells. It has been reported that this protein is over expressed in several human tumors, including mesothelioma, ovarian cancer, pancreatic adenocarcinoma, lung adenocarcinoma, and cholangiocarcinoma. Mesothelin can bind MUC16 (also known as CA125), indicating that the interaction of mesothelin and MUC16 may contribute to the implantation and peritoneal spread of tumors by cell adhesion. Since mesothelin is overexpressed in several cancers and is immunogenic, the protein could be exploited as tumor marker or as the antigenic target of a therapeutic cancer vaccine.
Synonyms MSLN; CAK1 antigen; CAK1; megakaryocyte potentiating factor; Mesothelin; MPF; MPFSMRP; Pre-pro-megakaryocyte-potentiating factor; SMR; soluble MPF mesothelin related protein

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.