Siglec-10, hFc, Human
Siglec-10 Fc Chimera, Human

Immobilized CD24-His (CD4-H52H3-100 µg) at 5 μg/ml (100 μl/well) can bind Siglec10 Fc Chimera, Human.

Siglec-10 Fc Chimera, Human

Siglec-10 is immune system-restricted and highly expressed in peripheral blood leukocytes. Siglec-10 preferably binds to α-2,3- or α-2,6-linked sialic acid (similarity). Siglec10 is involved in the negative regulation of B cell antigen receptor signal transduction. The inhibition of B cell activation depends on PTPN6/SHP-1 (by similarity). The binding of Siglec10 to CD24 may be involved in the selective suppression of the immune response (by similarity) to risk-related molecular patterns (DAMPs) (such as HMGB1, HSP70 and HSP90). The combination of Siglec10 and CD24 may regulate the immune response of natural killer (NK) cells. Play a role in controlling autoimmunity (by similarity). In the process of initiating an adaptive immune response by CD8-α+ dendritic cells, cross-presentation is inhibited by weakening the formation of MHC class I peptide complexes. The function seems to imply the recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex, thereby promoting phagosome acidification (by similarity).
Z03570
¥28,819.00

Ask us a question
Product Introduction
Species Human
Protein Construction
Siglec-10 (Met17-Thr546)
Accession # Q96LC7		 hFc
N-term C-term
Purity > 90% as analyzed by SDS-PAGE
Endotoxin Level < 1 EU/μg of protein by gel clotting method
Biological Activity Immobilized CD24-His (CD4-H52H3-100 µg) at 5.0 μg/ml (100 μl/well) can bind Siglec-10, hFc, Human.
Expression System HEK 293
Apparent Molecular Weight ~85.9 kDa, on SDS-PAGE under reducing conditions.
Formulation Supplied as a solution in PBS, pH 7.0-7.2.
Concentration Please refer to the COA for the specific lot.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at -20°C or below. Please avoid repeated freeze-thaw cycles.

Examples
  • Siglec-10 Fc Chimera, Human
    • Siglec-10 Fc Chimera, Human

    Immobilized CD24-His (CD4-H52H3-100 µg) at 5 μg/ml (100 μl/well) can bind Siglec10 Fc Chimera, Human.


Background
Target Background Siglec-10 is immune system-restricted and highly expressed in peripheral blood leukocytes. Siglec-10 preferably binds to α-2,3- or α-2,6-linked sialic acid (similarity). Siglec10 is involved in the negative regulation of B cell antigen receptor signal transduction. The inhibition of B cell activation depends on PTPN6/SHP-1 (by similarity). The binding of Siglec10 to CD24 may be involved in the selective suppression of the immune response (by similarity) to risk-related molecular patterns (DAMPs) (such as HMGB1, HSP70 and HSP90). The combination of Siglec10 and CD24 may regulate the immune response of natural killer (NK) cells. Play a role in controlling autoimmunity (by similarity). In the process of initiating an adaptive immune response by CD8-α+ dendritic cells, cross-presentation is inhibited by weakening the formation of MHC class I peptide complexes. The function seems to imply the recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex, thereby promoting phagosome acidification (by similarity).
Synonyms Sialic acid binding Ig-like lectin 10; MGC126774; PRO940; SIGLEC-10; SLG2

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.