DNAM-1/CD226, hFc, Human
DNAM-1/CD226 Fc Chimera, Human

DNAM-1/CD226 Fc Chimera, Human

DNAM-1/CD226 Fc Chimera, Human

Immobilized Rhesus macaque CD155/PVR Protein, His Tag at 1 μg/ml (100 μl/well) can bind DNAM-1/CD226 Fc Chimera, Human with an EC50 of 0.871 μg/ml when detected by Mouse Anti–Human IgG Fc-HRP. Background was subtracted from data points before curve fitting.

DNAM-1/CD226 Fc Chimera, Human

DNAM-1 (DNAX accessory molecule-1), also known as CD226, platelet and T cell activation antigen 1 (PTA1) and TLiSA1, is a member of the Ig superfamily containing two Ig-like domains of the V set and is encoded by a gene on human chromosome 18q22.3. DNAM-1 is an activating receptor expressed on natural killer (NK) cells, CD8+ T cells, and other immune cells. Upon recognition of its ligands, CD155 and CD112, DNAM-1 promotes NK cell–mediated elimination of transformed and virus-infected cells. It also has a key role in expansion and maintenance of virus-specific memory NK cells. DNAM-1 is the cell surface receptor of NECTIN2. Upon ligand binding, it stimulates T cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13 and IFNG.
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Product Introduction
Species Human
Protein Construction
DNAM-1/CD226 (Glu19-Asn247)
Accession # Q15762		 hFc
N-term C-term
Purity > 95% as analyzed by SDS-PAGE
Endotoxin Level < 1 EU/μg of protein by gel clotting method
Biological Activity Immobilized Rhesus macaque CD155/PVR Protein, His Tag at 1.0 μg/ml (100 μl/well) can bind DNAM-1/CD226, hFc, Human with an EC50 of 0.871 μg/ml when detected by Mouse Anti-Human IgG Fc-HRP.
Expression System HEK 293
Apparent Molecular Weight ~81.7 kDa, on SDS-PAGE under reducing conditions.
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

Examples
  • DNAM-1/CD226 Fc Chimera, Human
    • DNAM-1/CD226 Fc Chimera, Human

  • DNAM-1/CD226 Fc Chimera, Human
    • DNAM-1/CD226 Fc Chimera, Human

  • DNAM-1/CD226 Fc Chimera, Human
    • DNAM-1/CD226 Fc Chimera, Human

    Immobilized Rhesus macaque CD155/PVR Protein, His Tag at 1 μg/ml (100 μl/well) can bind DNAM-1/CD226 Fc Chimera, Human with an EC50 of 0.871 μg/ml when detected by Mouse Anti–Human IgG Fc-HRP. Background was subtracted from data points before curve fitting.


Background
Target Background DNAM-1 (DNAX accessory molecule-1), also known as CD226, platelet and T cell activation antigen 1 (PTA1) and TLiSA1, is a member of the Ig superfamily containing two Ig-like domains of the V set and is encoded by a gene on human chromosome 18q22.3. DNAM-1 is an activating receptor expressed on natural killer (NK) cells, CD8+ T cells, and other immune cells. Upon recognition of its ligands, CD155 and CD112, DNAM-1 promotes NK cell–mediated elimination of transformed and virus-infected cells. It also has a key role in expansion and maintenance of virus-specific memory NK cells. DNAM-1 is the cell surface receptor of NECTIN2. Upon ligand binding, it stimulates T cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13 and IFNG.
Synonyms DNAM-1; CD226; PTA1; TLiSA1

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.