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Sox2-TAT, Human

*This product has been discontinued!*
Sox2 is a member of the Sox family of transcription factors involved in mammalian development containing a highly conserved 79-residue DNA-binding domain, known as the high mobility group (HMG) box. Sox2 is a transcription factor that forms a trimeric complex with Oct4 and binds to DNA to promote the expression of pluripotent genes involved in self-renewal, while repressing genes involved in cell differentiation. Due to its high pluripotency, Sox2 is a commonly used transcription factor for generating induced-pluripotent stem cells (iPSCs).
Z03327
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Product Introduction
Species Human
Protein Construction

Expressed with a C-terminal TAT peptide.

Sox2-TAT (Met1-Met317)
Accession # P02775
Purity > 95% as analyzed by SDS-PAGE
Endotoxin Level < 0.2 EU/μg of protein by gel clotting method
Expression System HEK 293
Apparent Molecular Weight 50~55 kDa, on SDS-PAGE under reducing conditions.
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

Background
Target Background Sox2 is a member of the Sox family of transcription factors involved in mammalian development containing a highly conserved 79-residue DNA-binding domain, known as the high mobility group (HMG) box. Sox2 is a transcription factor that forms a trimeric complex with Oct4 and binds to DNA to promote the expression of pluripotent genes involved in self-renewal, while repressing genes involved in cell differentiation. Due to its high pluripotency, Sox2 is a commonly used transcription factor for generating induced-pluripotent stem cells (iPSCs).
Synonyms MCOPS3; ANOP3; MGC2413; SOX2; SRY (sex determining region Y)-box 2; (SRY)-box 2

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.