リコンビナントタンパク質＿精製したリコンビナントタンパク質 » リコンビナントサイトカイン-免疫活性タンパク質 » IL-4R, Human
IL-4 R, Human

ED₅₀< 70 ng/ml, measured in a neutralization assay using TF-1 cells in the presence of IL-4,Human(Z02925).

IL-4 R, Human

Interleukin-4 Receptor, also known as IL-4RA and CD124, is a transmembrane glycoprotein belonging to the class I receptor family. It is highly expressed by activated T-cells. IL-4RA couples with γ chain to form the type I receptor for IL-4. The extracellular domain of IL-4RA binds to IL-4 and antagonizes its activity. IL-4RA plays an important role in Th2 cell differentiation, Ig class switching and alternative macrophage activation. It has also been implicated in allergic inflammation, tumor progression and atherogenesis.
Z03150
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Product Introduction
Species Human
Protein Construction
IL-4R (Gly24-His232)
Accession # P24394
Purity > 95% as analyzed by SDS-PAGE
> 95% as analyzed by HPLC
Endotoxin Level < 0.2 EU/μg of protein by gel clotting method
Biological Activity ED50 < 70.0 ng/ml, measured in a neutralization assay using TF-1 cells in the presence of 0.5 ng/ml h-IL-4.
Expression System HEK 293
Apparent Molecular Weight 40~45 kDa, on SDS-PAGE under reducing conditions.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

Examples
  • IL-4 R, Human
    • IL-4 R, Human

    ED₅₀< 70 ng/ml, measured in a neutralization assay using TF-1 cells in the presence of IL-4,Human(Z02925).


Background
Target Background Interleukin-4 Receptor, also known as IL-4RA and CD124, is a transmembrane glycoprotein belonging to the class I receptor family. It is highly expressed by activated T-cells. IL-4RA couples with γ chain to form the type I receptor for IL-4. The extracellular domain of IL-4RA binds to IL-4 and antagonizes its activity. IL-4RA plays an important role in Th2 cell differentiation, Ig class switching and alternative macrophage activation. It has also been implicated in allergic inflammation, tumor progression and atherogenesis.
Synonyms IL4R; CD124; IL-4RA; IL4RA; Interleukin-4 receptor; interleukin 4 receptor

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.