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CD123 MRNA (Cap1, M1Ψ)

CD123 MRNA (Cap1, M1Ψ)

Expression of CD123 mRNA in A549 cells. GenSmart, X4, and X5 represent GenScript mRNA codon optimized using different algorithms.

CD123 mRNA (Cap1, m1Ψ)

CD123 is the alpha chain of the interleukin 3 receptor (IL-3R). It is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system.
RP-A00058
¥63,000.00

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Description

CD123 is the alpha chain of the interleukin 3 receptor (IL-3R). It is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system.  
 
This mRNA features: 
- A Cap 1 structure with high capping efficiency 
- Codon optimized using GenScript X5 algorithm to enhance expression efficiency 
- 100% substitution with N1-methyl-pseudouridine (m1Ψ) for improved protein expression and reduced innate immune response 
- GenScript’s patented UTR to enhance translation 
- A 100A poly(A) tail to mimic natural mature mRNA
Properties
Form Liquid
Concentration 1mg/mL
Full mRNA length 1402 nt
Full mRNA Molecular Weight 453088 Da
Storage buffer 1mM Sodium citrate, pH 6.5
Storage condition Store at -20°C for short term (<3 months), store at -80°C for long term.

Quality Control Specifications
Appearance Clear and free of foreign particles
RNA Length Expected size band detected
RNA Content Target ± 5%
Integrity ≥ 75%
OD260/OD280 1.70 ~ 2.30
Capping Efficiency ≥ 90%
Endotoxin < 10 EU/mg
pH Target ± 0.5

Applications
Transfect 0.5μg of CD123 mRNA into one well of cells in a 24-well plate with Lipofectamine™ MessengerMAX™ (or equivalent). 24-48 hours after transfection, detect the expression of CD123 protein using flow cytometry with staining by BD Pharmingen™ APC Mouse Anti-Human CD123 (Catalog No:560087).

Examples
  • CD123 MRNA (Cap1, M1Ψ)
    • CD123 MRNA (Cap1, M1Ψ)

  • CD123 MRNA (Cap1, M1Ψ)
    • CD123 MRNA (Cap1, M1Ψ)

    Expression of CD123 mRNA in A549 cells. GenSmart, X4, and X5 represent GenScript mRNA codon optimized using different algorithms.


For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.