Mouse Recombinant HVEM Stable Cell Line
CHO-K1/cyno TIGIT Stable Cell Line

FACS analysis of Cyno TIGIT expression in CHO-K1 cells.

CHO-K1/cyno TIGIT Stable Cell Line

HVEM is found on the surface of various cell types, including hematopoietic and non-hematopoietic cells, and is expressed mainly in spleen, thymus, bone marrow, lung and intestines. It has been identified as a canonical TNF receptor, signaling through the TNF receptor-associated factors (TRAFs) leading to NFκB activation. Furthermore, in addition to acting as a signaling receptor, in binding to Ig superfamily members it acts as a ligand for these inhibitory receptors. Therefore, bidirectional signaling is possible for the HVEM-mediated signaling network, which can be involved in positive or negative immunological reactions under different contexts.
M00672
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Description

TIGIT (T cell immunoreceptor with Ig and ITIM domains) was recently characterized as an inhibitory receptor, which is expressed mainly on NK, Treg, CD8+ T, and CD4+ T cells. TIGIT harbors an immunoglobulin tail tyrosine (ITT)-like phosphorylation motif and an ITIM (immunoreceptor tyrosine-based inhibition motif) in its cytoplasmic tail. The poliovirus receptor (PVR or CD155) was identified as the physical ligand of TIGIT with high affinity, and PVRL2 (Nectin2 or CD112) also binds to TIGIT with a weaker binding capacity. TIGIT/PVR engagement suppresses T cell activation through IL-10 secretion mediated by dendritic cells. Furthermore, TIGIT also exerts an intrinsic inhibitory function to T cell activation.
Synonyms

TNFRSF14

Product Introduction
Stability 15 passages
Storage Liquid nitrogen immediately upon receiving

Culture Conditions
Culture Medium F12K, 10% FBS, 8 μg/ml Puromycin
Freeze Medium-DATA 95% complete growth medium, 5% DMSO

Examples
  • CHO-K1/cyno TIGIT Stable Cell Line
    • CHO-K1/cyno TIGIT Stable Cell Line

    FACS analysis of Cyno TIGIT expression in CHO-K1 cells.