安定細胞株製品 » Human Recombinant Cannabinoid Receptor 2 Stable Cell Line
CHO-K1/CB2 Stable Cell Line

Figure 1. CP-55940-induced concentration-dependent stimulation of intracellular cAMP in CHO-K1/CNR2 cells. The EC50 of CP-55940 on this cell was 0.11 μM. Ratio = A660nm/B620nm x 104

CHO-K1/CB2 Stable Cell Line

The Cannabinoid receptor 2 (CNR2) is a Gi/o-coupled GPCR expressed in spleen, tonsils, bone marrow and peripheral blood leukocytes. There is one report that cannabinoid-induced inhibition of helper T cell activation is lost in macrophages obtained from CNR2 knockout mice. CNR2 is a potential therapeutic target in the treatment of various disease conditions, such as pain, multiple sclerosis, vascular disease, Parkinson's disease, and other central nerve system disorders.
M00433
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Description

The Cannabinoid receptor 2 (CNR2) is a Gi/o-coupled GPCR expressed in spleen, tonsils, bone marrow and peripheral blood leukocytes. There is one report that cannabinoid-induced inhibition of helper T cell activation is lost in macrophages obtained from CNR2 knockout mice. CNR2 is a potential therapeutic target in the treatment of various disease conditions, such as pain, multiple sclerosis, vascular disease, Parkinson's disease, and other central nerve system disorders.
Synonyms

CB2 receptor, Peripheral cannabinoid receptor, CB2, CB-2, cannabinoid receptor 2, cannabinoid receptor 2 gene, rCB2, CB2-R, cannabinoid receptor 2 (spleen)

Overview
Applications Functional assay for CB2 receptor

Product Introduction
Storage Liquid nitrogen immediately upon delivery
Species Human

Culture Conditions
Freeze Medium 45% culture medium, 45% FBS (Cat. #10099-141, Gibco), 10% DMSO (Cat. #D2650, Sigma)
Culture Medium Ham’s F-12K (Kaighn’s), 10% FBS, 400 µg/ml G418 (Cat. #10131-035, Gibco)

Examples
  • CHO-K1/CB2 Stable Cell Line
    • CHO-K1/CB2 Stable Cell Line

    Figure 1. CP-55940-induced concentration-dependent stimulation of intracellular cAMP in CHO-K1/CNR2 cells. The EC50 of CP-55940 on this cell was 0.11 μM. Ratio = A660nm/B620nm x 104