安定細胞株製品 » Human Recombinant H3 Histamine Receptor Stable Cell Line
CHO-K1/H3/Gα15 Stable Cell Line

CHO-K1/H3/Gα15 Stable Cell Line

The histamine receptor H3 is a Gi-coupled GPCR expressed in the thalamus, caudate nucleus, putamen, cerebellum, amygdala, substantia nigra, hippocampus, hypothalamus and cerebral cortex. Activation of H3 receptor in human nasal mucosa inhibits sympathetic vasoconstriction. Expression of human H3 receptor splice variants in CHO cells shows that a deletion in the 2nd transmembrane domain alters ligand binding and deletions in the 3rd intracellular loop result in signal transduction being abolished.
M00331
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Description

The histamine receptor H3 is a Gi-coupled GPCR expressed in the thalamus, caudate nucleus, putamen, cerebellum, amygdala, substantia nigra, hippocampus, hypothalamus and cerebral cortex. Activation of H3 receptor in human nasal mucosa inhibits sympathetic vasoconstriction. Expression of human H3 receptor splice variants in CHO cells shows that a deletion in the 2nd transmembrane domain alters ligand binding and deletions in the 3rd intracellular loop result in signal transduction being abolished.
Synonyms

H3 receptor, GPCR97, MGC105370, H3R, HH3R, histamine H3 receptor, AW049250

Product Introduction
Storage Liquid nitrogen immediately upon delivery

Culture Conditions
Culture Medium Ham’s F-12K (Kaighn’s), 10% FBS, 100 μg/ml Hygromycin B (Cat. #10687010, Invitrogen), 400 μg/ml G418 (Cat. #10131-035, Gibco)
Freeze Medium-DATA 45% culture medium, 45% FBS (Cat. #10099-141, Gibco), 10% DMSO (Cat. #D2650, Sigma)

Examples
  • CHO-K1/H3/Gα15 Stable Cell Line
    • CHO-K1/H3/Gα15 Stable Cell Line