CD40 cDNA ORF clone, Sus scrofa(pig)

Gene
Clones
gRNAs

Summary

Gene Symbol	CD40
Entrez Gene ID	397395
Full Name	CD40 molecule
Synonyms	TNFRSF5
Gene Type	protein-coding
Organism	Sus scrofa(pig)
Genome	Chromosome: 17 Map Location: 17\|17

mRNA and Protein(s)

mRNA	Protein	Name
NM_214194.1	NP_999359.1	tumor necrosis factor receptor superfamily member 5 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

CD40 engagement strongly induces CD25 expression on porcine dendritic cells and polarizes the T cell immune response toward Th1.
Pilon C, Levast B, Meurens F, Le Vern Y, Kerboeuf D, Salmon H, Velge-Roussel F, Lebranchu Y, Baron C
Molecular immunology46(3)437-47(2009 Jan)

Xenogeneic interaction between human CD40L and porcine CD40 activates porcine endothelial cells through NF-kappaB signaling.
Choi I, Kim SD, Cho B, Kim D, Park D, Koh HS, Kim BY, Kim JY, Yang J, Ahn C
Molecular immunology45(2)575-80(2008 Jan)

PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences.
Uenishi H, Eguchi-Ogawa T, Shinkai H, Okumura N, Suzuki K, Toki D, Hamasima N, Awata T
Nucleic acids research35(Database issue)D650-3(2007 Jan)

Internalization of CD40 regulates its signal transduction in vascular endothelial cells.
Chen Y, Chen J, Xiong Y, Da Q, Xu Y, Jiang X, Tang H
Biochemical and biophysical research communications345(1)106-17(2006 Jun)

PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries.
Uenishi H, Eguchi T, Suzuki K, Sawazaki T, Toki D, Shinkai H, Okumura N, Hamasima N, Awata T
Nucleic acids research32(Database issue)D484-8(2004 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The appearance of CD25 after activation of porcine dendritic cells, is reported.
Title: CD40 engagement strongly induces CD25 expression on porcine dendritic cells and polarizes the T cell immune response toward Th1.

This study shows that xenogeneic interaction between hCD40L and pCD40 can activate porcine endothelial cells through NF-kappaB signaling.
Title: Xenogeneic interaction between human CD40L and porcine CD40 activates porcine endothelial cells through NF-kappaB signaling.

These results therefore may help understand the molecular mechanism of CD40L signaling that contributes to the pathophysiology of atherosclerosis.
Title: Internalization of CD40 regulates its signal transduction in vascular endothelial cells.

The following CD40 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CD40 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSe30490	NM_214194.1 Latest version!	Sus scrofa CD40 molecule (CD40), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CD40 ( NM_214194.1 ) cDNA ORF clone, Sus scrofa(pig) -> NP_999359.1 Sus scrofa CD40 molecule (CD40), mRNA.

Price & Availability↑

CloneID	OSe30490
Clone ID Related Accession (Same CDS sequence)	NM_214194.1
Accession Version	NM_214194.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 837bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Sus scrofa(pig)
Product	tumor necrosis factor receptor superfamily member 5 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF248545.1. ##Evidence-Data-START## Transcript exon combination :: AF248545.1, AK351268.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2040857, SAMEA2040998 [ECO:0000348] ##Evidence-Data-END##

ATGGTTCGTC TGCCTCTGAA GTGTCTCCTC TGGGGCTGCT TTTTGACCGC CGTCCACCCA 
GAACCACCCA CTTCATGCAA AGAGAACCAA TACCCAACAA ACAGCCGGTG CTGTAATTTG 
TGCCCGCCAG GACAGAAACT GGTGAACCAC TGCACAGAGG TCACTGAAAC AGAATGCCTT 
CCTTGCAGTT CCAGCGAATT CCTAGCCACC TGGAATAGAG AGAAACACTG TCATCAGCAC 
AAATACTGCG ACCCCAACCT AGGTCTCCAG GTCCAGAGGG AGGGCACCTC GAAAACAGAC 
ACCACTTGTG TGTGCAGTGA AGGCCATCAC TGTACCAACA GCGCCTGTGA AAGTTGCACC 
TTGCACAGCT TGTGCTTCCC TGGCCTCGGG GTCAAGCAGA TGGCGACAGA GGTTTCTGAC 
ACTATCTGTG AACCCTGCCC AGTTGGCTTC TTCTCCAATG TATCATCTGC TTCAGAAAAG 
TGTCAGCCTT GGACAAGCTG CGAGAGCAAA GGCCTGGTGG AACAACGTGC GGGGACTAAC 
AAGACCGATG TTGTCTGTGG TTTCCAGAGT CGGATGAGAG CCCTGGTGGT TATCCCCATC 
ACGCTGGGGA TCCTGTTTGC CGTCCTGTTG GTATTTCTCT GTATCAGAAA GGTGACCAAG 
GAGCAGGAGA CTAAGGCCCT GCACCCTAAG ACTGAAAGGC AGGATCCCGT GGAGACGATT 
GATCTGGAGG ATTTTCCCGA CTCCACCGCT CCGGTGCAGG AGACCTTACA TTGGTGCCAG 
CCCGTCACCC AGGAGGATGG CAAAGAGAGC CGCATCTCCG TGCAGGAGCG AGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_999359.1
CDS	1..837
Translation	MVRLPLKCLLWGCFLTAVHPEPPTSCKENQYPTNSRCCNLCPPGQKLVNHCTEVTETECLPCSSSEFLATWNREKHCHQHKYCDPNLGLQVQREGTSKTDTTCVCSEGHHCTNSACESCTLHSLCFPGLGVKQMATEVSDTICEPCPVGFFSNVSSASEKCQPWTSCESKGLVEQRAGTNKTDVVCGFQSRMRALVVIPITLGILFAVLLVFLCIRKVTKEQETKALHPKTERQDPVETIDLEDFPDSTAPVQETLHWCQPVTQEDGKESRISVQERE

Target ORF information:

RefSeq Version	NM_214194.1
Organism	Sus scrofa(pig)
Definition	Sus scrofa CD40 molecule (CD40), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_214194.1

ORF Insert Sequence:

ATGGTTCGTC TGCCTCTGAA GTGTCTCCTC TGGGGCTGCT TTTTGACCGC CGTCCACCCA 
GAACCACCCA CTTCATGCAA AGAGAACCAA TACCCAACAA ACAGCCGGTG CTGTAATTTG 
TGCCCGCCAG GACAGAAACT GGTGAACCAC TGCACAGAGG TCACTGAAAC AGAATGCCTT 
CCTTGCAGTT CCAGCGAATT CCTAGCCACC TGGAATAGAG AGAAACACTG TCATCAGCAC 
AAATACTGCG ACCCCAACCT AGGTCTCCAG GTCCAGAGGG AGGGCACCTC GAAAACAGAC 
ACCACTTGTG TGTGCAGTGA AGGCCATCAC TGTACCAACA GCGCCTGTGA AAGTTGCACC 
TTGCACAGCT TGTGCTTCCC TGGCCTCGGG GTCAAGCAGA TGGCGACAGA GGTTTCTGAC 
ACTATCTGTG AACCCTGCCC AGTTGGCTTC TTCTCCAATG TATCATCTGC TTCAGAAAAG 
TGTCAGCCTT GGACAAGCTG CGAGAGCAAA GGCCTGGTGG AACAACGTGC GGGGACTAAC 
AAGACCGATG TTGTCTGTGG TTTCCAGAGT CGGATGAGAG CCCTGGTGGT TATCCCCATC 
ACGCTGGGGA TCCTGTTTGC CGTCCTGTTG GTATTTCTCT GTATCAGAAA GGTGACCAAG 
GAGCAGGAGA CTAAGGCCCT GCACCCTAAG ACTGAAAGGC AGGATCCCGT GGAGACGATT 
GATCTGGAGG ATTTTCCCGA CTCCACCGCT CCGGTGCAGG AGACCTTACA TTGGTGCCAG 
CCCGTCACCC AGGAGGATGG CAAAGAGAGC CGCATCTCCG TGCAGGAGCG AGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CD40 engagement strongly induces CD25 expression on porcine dendritic cells and polarizes the T cell immune response toward Th1.
Molecular immunology46(3)437-47(2009 Jan)
Pilon C,Levast B,Meurens F,Le Vern Y,Kerboeuf D,Salmon H,Velge-Roussel F,Lebranchu Y,Baron C

Xenogeneic interaction between human CD40L and porcine CD40 activates porcine endothelial cells through NF-kappaB signaling.
Molecular immunology45(2)575-80(2008 Jan)
Choi I,Kim SD,Cho B,Kim D,Park D,Koh HS,Kim BY,Kim JY,Yang J,Ahn C

PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences.
Nucleic acids research35(Database issue)D650-3(2007 Jan)
Uenishi H,Eguchi-Ogawa T,Shinkai H,Okumura N,Suzuki K,Toki D,Hamasima N,Awata T

Internalization of CD40 regulates its signal transduction in vascular endothelial cells.
Biochemical and biophysical research communications345(1)106-17(2006 Jun)
Chen Y,Chen J,Xiong Y,Da Q,Xu Y,Jiang X,Tang H

PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries.
Nucleic acids research32(Database issue)D484-8(2004 Jan)
Uenishi H,Eguchi T,Suzuki K,Sawazaki T,Toki D,Shinkai H,Okumura N,Hamasima N,Awata T

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CD40 cDNA ORF clone, Sus scrofa(pig)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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