ITGB3 cDNA ORF clone, Sus scrofa(pig)

Gene
Clones
gRNAs

Summary

Gene Symbol	ITGB3
Entrez Gene ID	397063
Full Name	integrin subunit beta 3
Synonyms	CD61
Gene Type	protein-coding
Organism	Sus scrofa(pig)

mRNA and Protein(s)

mRNA	Protein	Name
NM_214002.1	NP_999167.1	integrin beta-3 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Contribution of activated beta3 integrin in the PDI release from endothelial cells.
Ponamarczuk H, Popielarski M, Stasiak M, Bednarek R, Studzian M, Pulaski L, Babinska A, Swiatkowska M
Frontiers in bioscience (Landmark edition)231612-1627(2018 Mar)

An anti-?V?3 antibody inhibits coronary artery atherosclerosis in diabetic pigs.
Maile LA, Busby WH, Xi G, Gollahan KP, Flowers W, Gafbacik N, Gafbacik S, Stewart K, Merricks EP, Nichols TC, Bellinger DA, Clemmons DR
Atherosclerosis25840-50(2017 Mar)

Integrin ?3 is required in infection and proliferation of classical swine fever virus.
Li W, Wang G, Liang W, Kang K, Guo K, Zhang Y
PloS one9(10)e110911(2014)

Shear stress induces the release of an endothelial elastase: role in integrin ?(v)?(3)-mediated FGF-2 release.
Hennig T, Mogensen C, Kirsch J, Pohl U, Gloe T
Journal of vascular research48(6)453-64(2011)

Molecular characterization and expression analysis of porcine integrins alphavbeta3, alphavbeta6 and alphavbeta8 that are potentially involved in FMDV infection.
Du J, Chang H, Gao S, Xue S, Cong G, Shao J, Lin T, Liu Z, Liu X, Cai X
Molecular and cellular probes24(5)256-65(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Blocking ligand binding to the alphaVbeta3 integrin inhibits its activation and prevents coronary artery atherosclerosis in diabetic pigs.
Title: An anti-?V?3 antibody inhibits coronary artery atherosclerosis in diabetic pigs.

integrin beta3 is required in CSFV infection and proliferation
Title: Integrin ?3 is required in infection and proliferation of classical swine fever virus.

The observed effects of shear stress on integrin alpha(v)beta(3) and p38 MAPK activation, as well as on FGF-2 release could be mimicked by application of pancreatic elastase to static endothelial cells.
Title: Shear stress induces the release of an endothelial elastase: role in integrin ?(v)?(3)-mediated FGF-2 release.

Data show that integrin alphav, beta3, beta6 and beta8 subunit shares common structural and functional elements.
Title: Molecular characterization and expression analysis of porcine integrins alphavbeta3, alphavbeta6 and alphavbeta8 that are potentially involved in FMDV infection.

Up-regulation of integrin beta3 expression in vascular endothelial cells cultured in vitro by classical swine fever virus.
Title: Up-regulation of integrin beta3 expression in porcine vascular endothelial cells cultured in vitro by classical swine fever virus.

The following ITGB3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ITGB3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSe28857	NM_214002.1 Latest version!	Sus scrofa integrin subunit beta 3 (ITGB3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ITGB3 ( NM_214002.1 ) cDNA ORF clone, Sus scrofa(pig) -> NP_999167.1 Sus scrofa integrin subunit beta 3 (ITGB3), mRNA.

Price & Availability↑

CloneID	OSe28857
Clone ID Related Accession (Same CDS sequence)	NM_214002.1
Accession Version	NM_214002.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2355bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-02
Organism	Sus scrofa(pig)
Product	integrin beta-3 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF282890.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF282890.1, AF170527.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1487420, SAMEA1876824 [ECO:0000350] ##Evidence-Data-END##

ATGCGAGCGC GGCCGCTCTG GGCCGCTGTG CTGGTGGTGG GGGCGCTGGC GGGCGTCGGC 
GTCGGAGGGC CCAACATCTG TGCCACACGA GGTGTGAGCT CCTGCCAGCA ATGTCTGGCT 
GTGAGTCCCA TGTGTGCCTG GTGCTCAGAT GAGGATCTGC CTCTGGGCAC GCCCCGCTGT 
AACCTGGAGG AGAATCTGCT GAACGATCAC TGTAACCCGA AGTACATTGA GTTCCCCATC 
AGTGAGGCCA GAATCCTGGA GGCCAGGCCC CTGAGTGACA AGGGCTCTGG AGACAGCTCC 
CAGATAACTC AAGTCAGCCC CCAGAGGATC TTGCTCCGGC TCCGGCCAGA TGATTCGAAG 
AGTTTCTCCG TCCAAGTCCG GCAGGTGGAG GATTACCCTG TGGACATCTA CTACTTGATG 
GACCTGTCTT TCTCTATGAA GGATGATCTG GAGAGCATCC AGAACCTGGG TACCAAGCTG 
GCTTCCCAGA TGCGTAAGCT CACCAGTAAC CTGCGGATTG GCTTCGGGGC CTTTGTGGAC 
AAGCCTGTGT CACCTTACAT GTACATCTCT CCACCACAGG CCCTCAAAAA CCCCTGCTAT 
GATATGAAGA CCACCTGTTT GCCCATGTTT GGCTACAAAC ATGTGCTCAC ACTAACTGAC 
CAGGTGACCC GTTTCAACGA GGAAGTGAAG AAGCAGAATG TATCACGGAA CCGAGATGCT 
CCAGAGGGTG GCTTTGATGC CATCATGCAG GCTACTGTCT GTGACGAGAA GATTGGCTGG 
AGGAACGATG CATCCCACTT ACTGGTGTTT ACCACTGATG CCAAGACCCA TATAGCGCTG 
GATGGAAGGC TGGCAGGCAT TGTCCAACCC AATGATGGAC AGTGTCATGT TGGCAGTGAC 
AACCATTACT CTGCCTCCAC TACCATGGAT TATCCCTCTC TGGGGCTGAT AACTGAGAAG 
CTATCCCAGA AAAACATCAA TTTGATCTTT GCAGTGACAG AAGGTGTAGT TAGTCTTTAC 
CAGAACTACA GTGAACTGAT CCCAGGGACC ACAGTGGGGG TGCTGTCCTC CAATTCCAGC 
AATGTCCTCC AGCTCATTGT GGATGCTTAT GGCAAAATCC GCTCTAAAGT GGAGCTCGAA 
GTGCGTGACC TCCCTGAGGA GCTGTCGTTA TCCTTCAATG CCACCTGTCT CAACAACGAG 
GTCATCCCAG GCCTTAAGTC TTGTGTTGGA CTCAAGATTG GAGACACGGT GAGCTTCAGC 
ATTGAGGCCA AGGTGCGTGG CTGCCCCCGG GAGAAGGAGA AGTCCTTCAC CATCAAGCCC 
GTGGGCTTCA AAGACAGCCT CACTGTCCAG GTCACCTTCA ACTGTGACTG TGACTGCCAG 
GCTCAAGCTG AGCCTGACAG CCCCCGCTGC AACAATGGCA ATGGGACCTT TGAGTGTGGG 
GTGTGCCACT GTGGGCCTGG CTGGCTGGGG TTCCAGTGTG AGTGCTCGGA AAAGGACTAC 
CGCCCCTCCC AGCAGGATGA GTGCAGCCCC CAGCAGGGCC AGCCCATCTG CAGCCAGCGG 
GGCGAGTGTC TCTGTGGCCA GTGTGTCTGC CACAGCAGTG ACTTTGGCAA GATCACGGGC 
AAGTACTGTG AGTGTGACGA CTTCTCCTGT GTCCACTACA AGGGGGAGAT GTGCTCAGGC 
CATGGCCAGT GCAGCTGCGG GGACTGTCTG TGTGACTCCG ACTGGACTGG CTTCTACTGC 
AACTGTACCA CGCGCACCGA CACCTGCTTG TCTAGCAACG GGCTGCTGTG CAGCGGGCGG 
GGCAATTGCG AATGCGGCAG CTGCGTCTGC ATCCAGCCAG GCTCCTACGG GGACACCTGT 
GAGAAGTGTC CCACTTGCCC TGATGCCTGC ACCTTTAAGA AGGGGTGTGT GGAGTGTAAA 
AAGTTTAACC GGGGATCCCT CTACGAGGCA AATACTTGCA ACCGTTACTG TCGTGATGAG 
ATTGAGTCTG TGAAGGAGCT TCAGGACAGT GGCAAGAATG CAGTGAATTG TACCTACAAG 
AATGAGGATG ACTGTGTCGT CAGATTCCAG TACTATGAAG ACTCCAGTGG AAAGTCCATC 
CTGTATGTGG TAGAAGAGCC AGAGTGTCCC AAGGGCCCTG ACATCCTGGT GGTCCTGCTT 
TCAGTGATGG GGGCCATTCT GCTCATCGGC CTTGCTACTC TGCTCATCTG GAAGCTCCTC 
ATCACCATCC ATGACCGGAA GGAGTTTGCT AAATTTGAAG AAGAGAGAGC CAGAGCCAAA 
TGGGACACAG CCAACAATCC CCTGTATAAA GAGGCCACAT CCACCTTCAC CAACATCACC 
TACCGGGGCA CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_999167.1
CDS	32..2386
Translation	MRARPLWAAVLVVGALAGVGVGGPNICATRGVSSCQQCLAVSPMCAWCSDEDLPLGTPRCNLEENLLNDHCNPKYIEFPISEARILEARPLSDKGSGDSSQITQVSPQRILLRLRPDDSKSFSVQVRQVEDYPVDIYYLMDLSFSMKDDLESIQNLGTKLASQMRKLTSNLRIGFGAFVDKPVSPYMYISPPQALKNPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQNVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLITEKLSQKNINLIFAVTEGVVSLYQNYSELIPGTTVGVLSSNSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCVGLKIGDTVSFSIEAKVRGCPREKEKSFTIKPVGFKDSLTVQVTFNCDCDCQAQAEPDSPRCNNGNGTFECGVCHCGPGWLGFQCECSEKDYRPSQQDECSPQQGQPICSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVHYKGEMCSGHGQCSCGDCLCDSDWTGFYCNCTTRTDTCLSSNGLLCSGRGNCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKGCVECKKFNRGSLYEANTCNRYCRDEIESVKELQDSGKNAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDILVVLLSVMGAILLIGLATLLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT

Target ORF information:

RefSeq Version	NM_214002.1
Organism	Sus scrofa(pig)
Definition	Sus scrofa integrin subunit beta 3 (ITGB3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_214002.1

ORF Insert Sequence:

ATGCGAGCGC GGCCGCTCTG GGCCGCTGTG CTGGTGGTGG GGGCGCTGGC GGGCGTCGGC 
GTCGGAGGGC CCAACATCTG TGCCACACGA GGTGTGAGCT CCTGCCAGCA ATGTCTGGCT 
GTGAGTCCCA TGTGTGCCTG GTGCTCAGAT GAGGATCTGC CTCTGGGCAC GCCCCGCTGT 
AACCTGGAGG AGAATCTGCT GAACGATCAC TGTAACCCGA AGTACATTGA GTTCCCCATC 
AGTGAGGCCA GAATCCTGGA GGCCAGGCCC CTGAGTGACA AGGGCTCTGG AGACAGCTCC 
CAGATAACTC AAGTCAGCCC CCAGAGGATC TTGCTCCGGC TCCGGCCAGA TGATTCGAAG 
AGTTTCTCCG TCCAAGTCCG GCAGGTGGAG GATTACCCTG TGGACATCTA CTACTTGATG 
GACCTGTCTT TCTCTATGAA GGATGATCTG GAGAGCATCC AGAACCTGGG TACCAAGCTG 
GCTTCCCAGA TGCGTAAGCT CACCAGTAAC CTGCGGATTG GCTTCGGGGC CTTTGTGGAC 
AAGCCTGTGT CACCTTACAT GTACATCTCT CCACCACAGG CCCTCAAAAA CCCCTGCTAT 
GATATGAAGA CCACCTGTTT GCCCATGTTT GGCTACAAAC ATGTGCTCAC ACTAACTGAC 
CAGGTGACCC GTTTCAACGA GGAAGTGAAG AAGCAGAATG TATCACGGAA CCGAGATGCT 
CCAGAGGGTG GCTTTGATGC CATCATGCAG GCTACTGTCT GTGACGAGAA GATTGGCTGG 
AGGAACGATG CATCCCACTT ACTGGTGTTT ACCACTGATG CCAAGACCCA TATAGCGCTG 
GATGGAAGGC TGGCAGGCAT TGTCCAACCC AATGATGGAC AGTGTCATGT TGGCAGTGAC 
AACCATTACT CTGCCTCCAC TACCATGGAT TATCCCTCTC TGGGGCTGAT AACTGAGAAG 
CTATCCCAGA AAAACATCAA TTTGATCTTT GCAGTGACAG AAGGTGTAGT TAGTCTTTAC 
CAGAACTACA GTGAACTGAT CCCAGGGACC ACAGTGGGGG TGCTGTCCTC CAATTCCAGC 
AATGTCCTCC AGCTCATTGT GGATGCTTAT GGCAAAATCC GCTCTAAAGT GGAGCTCGAA 
GTGCGTGACC TCCCTGAGGA GCTGTCGTTA TCCTTCAATG CCACCTGTCT CAACAACGAG 
GTCATCCCAG GCCTTAAGTC TTGTGTTGGA CTCAAGATTG GAGACACGGT GAGCTTCAGC 
ATTGAGGCCA AGGTGCGTGG CTGCCCCCGG GAGAAGGAGA AGTCCTTCAC CATCAAGCCC 
GTGGGCTTCA AAGACAGCCT CACTGTCCAG GTCACCTTCA ACTGTGACTG TGACTGCCAG 
GCTCAAGCTG AGCCTGACAG CCCCCGCTGC AACAATGGCA ATGGGACCTT TGAGTGTGGG 
GTGTGCCACT GTGGGCCTGG CTGGCTGGGG TTCCAGTGTG AGTGCTCGGA AAAGGACTAC 
CGCCCCTCCC AGCAGGATGA GTGCAGCCCC CAGCAGGGCC AGCCCATCTG CAGCCAGCGG 
GGCGAGTGTC TCTGTGGCCA GTGTGTCTGC CACAGCAGTG ACTTTGGCAA GATCACGGGC 
AAGTACTGTG AGTGTGACGA CTTCTCCTGT GTCCACTACA AGGGGGAGAT GTGCTCAGGC 
CATGGCCAGT GCAGCTGCGG GGACTGTCTG TGTGACTCCG ACTGGACTGG CTTCTACTGC 
AACTGTACCA CGCGCACCGA CACCTGCTTG TCTAGCAACG GGCTGCTGTG CAGCGGGCGG 
GGCAATTGCG AATGCGGCAG CTGCGTCTGC ATCCAGCCAG GCTCCTACGG GGACACCTGT 
GAGAAGTGTC CCACTTGCCC TGATGCCTGC ACCTTTAAGA AGGGGTGTGT GGAGTGTAAA 
AAGTTTAACC GGGGATCCCT CTACGAGGCA AATACTTGCA ACCGTTACTG TCGTGATGAG 
ATTGAGTCTG TGAAGGAGCT TCAGGACAGT GGCAAGAATG CAGTGAATTG TACCTACAAG 
AATGAGGATG ACTGTGTCGT CAGATTCCAG TACTATGAAG ACTCCAGTGG AAAGTCCATC 
CTGTATGTGG TAGAAGAGCC AGAGTGTCCC AAGGGCCCTG ACATCCTGGT GGTCCTGCTT 
TCAGTGATGG GGGCCATTCT GCTCATCGGC CTTGCTACTC TGCTCATCTG GAAGCTCCTC 
ATCACCATCC ATGACCGGAA GGAGTTTGCT AAATTTGAAG AAGAGAGAGC CAGAGCCAAA 
TGGGACACAG CCAACAATCC CCTGTATAAA GAGGCCACAT CCACCTTCAC CAACATCACC 
TACCGGGGCA CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Contribution of activated beta3 integrin in the PDI release from endothelial cells.
Frontiers in bioscience (Landmark edition)231612-1627(2018 Mar)
Ponamarczuk H,Popielarski M,Stasiak M,Bednarek R,Studzian M,Pulaski L,Babinska A,Swiatkowska M

An anti-?V?3 antibody inhibits coronary artery atherosclerosis in diabetic pigs.
Atherosclerosis25840-50(2017 Mar)
Maile LA,Busby WH,Xi G,Gollahan KP,Flowers W,Gafbacik N,Gafbacik S,Stewart K,Merricks EP,Nichols TC,Bellinger DA,Clemmons DR

Integrin ?3 is required in infection and proliferation of classical swine fever virus.
PloS one9(10)e110911(2014)
Li W,Wang G,Liang W,Kang K,Guo K,Zhang Y

Shear stress induces the release of an endothelial elastase: role in integrin ?(v)?(3)-mediated FGF-2 release.
Journal of vascular research48(6)453-64(2011)
Hennig T,Mogensen C,Kirsch J,Pohl U,Gloe T

Molecular characterization and expression analysis of porcine integrins alphavbeta3, alphavbeta6 and alphavbeta8 that are potentially involved in FMDV infection.
Molecular and cellular probes24(5)256-65(2010 Oct)
Du J,Chang H,Gao S,Xue S,Cong G,Shao J,Lin T,Liu Z,Liu X,Cai X