OAZ1 cDNA ORF clone, Sus scrofa(pig)

Gene
Clones
gRNAs

Summary

Gene Symbol	OAZ1
Entrez Gene ID	397034
Full Name	ornithine decarboxylase antizyme 1
Synonyms	AZ1
Gene Type	protein-coding
Organism	Sus scrofa(pig)
Summary	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as by inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization (PMID:16120325). Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jul 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001122994.2	NP_001116466.1	ornithine decarboxylase antizyme 1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Molecular characterization, tissue expression and nucleotide variation of the porcine AZ1 gene.
Zhang AL, Wu XY, Li JQ, Zhang Z, Zhang H
Gene501(1)79-84(2012 Jun)

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Ivanov IP, Atkins JF
Nucleic acids research35(6)1842-58(2007)

Porcine transcriptome analysis based on 97 non-normalized cDNA libraries and assembly of 1,021,891 expressed sequence tags.
Gorodkin J, Cirera S, Hedegaard J, Gilchrist MJ, Panitz F, J?rgensen C, Scheibye-Knudsen K, Arvin T, Lumholdt S, Sawera M, Green T, Nielsen BJ, Havgaard JH, Rosenkilde C, Wang J, Li H, Li R, Liu B, Hu S, Dong W, Li W, Yu J, Wang J, Staefeldt HH, Wernersson R, Madsen LB, Thomsen B, Hornsh?j H, Bujie Z, Wang X, Wang X, Bolund L, Brunak S, Yang H, Bendixen C, Fredholm M
Genome biology8(4)R45(2007)

PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences.
Uenishi H, Eguchi-Ogawa T, Shinkai H, Okumura N, Suzuki K, Toki D, Hamasima N, Awata T
Nucleic acids research35(Database issue)D650-3(2007 Jan)

Mitochondrial localization of antizyme is determined by context-dependent alternative utilization of two AUG initiation codons.
Gandre S, Bercovich Z, Kahana C
Mitochondrion2(4)245-56(2003 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Expression patterns showed that in Lantang pig, the AZ1 gene is differentially expressed in various tissues and displayed higher expression in lung and skeletal muscle
Title: Molecular characterization, tissue expression and nucleotide variation of the porcine AZ1 gene.

The following OAZ1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OAZ1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSe101266	NM_001122994.2 Latest version!	Sus scrofa ornithine decarboxylase antizyme 1 (OAZ1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OAZ1 ( NM_001122994.2 ) cDNA ORF clone, Sus scrofa(pig) -> NP_001116466.1 Sus scrofa ornithine decarboxylase antizyme 1 (OAZ1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OSe101266
Clone ID Related Accession (Same CDS sequence)	NM_001122994.2
Accession Version	NM_001122994.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-11
Organism	Sus scrofa(pig)
Product	ornithine decarboxylase antizyme 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BW984205.1, AK392488.1 and EW617964.2. On Jul 15, 2014 this sequence version replaced NM_001122994.1. Transcript Variant: This variant (1) represents the protein-coding transcript. ##Evidence-Data-START## Transcript exon combination :: BW984205.1, AK392488.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01048242, SAMN01048247 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGAAAT CCTCCCTGCA GCGGATCCTC AACAGCCACT GCTTCGCCAG AGAGAAGGAG 
GGGGATAAAC CCAGCGCCAC CGTCCACGCC ACCCGCACCA TGCCGCTCCT CAGCCTGCAC 
AGCCGCGGAG GCCGCAGCAG CGAGAGTTCC AGGGTCTCCA TCAACTGCTG TAGTAACCTG 
GGTCCAGGGC CTCGGTGGTG CTCCGATGTC CCTCACCCAC CCCTGAAGAT CCCAGGTGGG 
CGAGGGAATA GTCAGAGGGA TCACAATCTT TCAGCTAATT TATTTTACTC TGATAATCGG 
CTGAATGTAA CAGAGGAACT AACGTCTAAT AACAAGACGA GAATTTTAAA CGTCCAATCC 
AGGCTCACAG ATGCCAAACA CATTAACTGG AGAGCGGTGC TGAGCAATAG CTGCCTCTAC 
ATCGAGATCC CAGGCGGCGC TCTGCCCGAG GGGAGCAAGG ACAGCTTTGC AGTTCTTCTC 
GAATTTGCTG AGGAGCAGCT CCACGCTGAC CATGTCTTCA TTTGCTTCCA CAAGAACCGC 
GAGGACAGAG CCGCCTTGCT CCGTACCTTC AGCTTTTTGG GCTTTGAGAT TGTGAGACCG 
GGGCATCCCC TTGTCCCCAA GAGACCCGAC GCTTGCTTCA TGGCCTACAC GTTTGAGAGA 
GAGTCCTCTG GTGAGGAGGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001116466.1
CDS	join(81..284,286..765)
Translation	MVKSSLQRILNSHCFAREKEGDKPSATVHATRTMPLLSLHSRGGRSSESSRVSINCCSNLGPGPRWCSDVPHPPLKIPGGRGNSQRDHNLSANLFYSDNRLNVTEELTSNNKTRILNVQSRLTDAKHINWRAVLSNSCLYIEIPGGALPEGSKDSFAVLLEFAEEQLHADHVFICFHKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMAYTFERESSGEEE

Target ORF information:

RefSeq Version	NM_001122994.2
Organism	Sus scrofa(pig)
Definition	Sus scrofa ornithine decarboxylase antizyme 1 (OAZ1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001122994.2

ORF Insert Sequence:

ATGGTGAAAT CCTCCCTGCA GCGGATCCTC AACAGCCACT GCTTCGCCAG AGAGAAGGAG 
GGGGATAAAC CCAGCGCCAC CGTCCACGCC ACCCGCACCA TGCCGCTCCT CAGCCTGCAC 
AGCCGCGGAG GCCGCAGCAG CGAGAGTTCC AGGGTCTCCA TCAACTGCTG TAGTAACCTG 
GGTCCAGGGC CTCGGTGGTG CTCCGATGTC CCTCACCCAC CCCTGAAGAT CCCAGGTGGG 
CGAGGGAATA GTCAGAGGGA TCACAATCTT TCAGCTAATT TATTTTACTC TGATAATCGG 
CTGAATGTAA CAGAGGAACT AACGTCTAAT AACAAGACGA GAATTTTAAA CGTCCAATCC 
AGGCTCACAG ATGCCAAACA CATTAACTGG AGAGCGGTGC TGAGCAATAG CTGCCTCTAC 
ATCGAGATCC CAGGCGGCGC TCTGCCCGAG GGGAGCAAGG ACAGCTTTGC AGTTCTTCTC 
GAATTTGCTG AGGAGCAGCT CCACGCTGAC CATGTCTTCA TTTGCTTCCA CAAGAACCGC 
GAGGACAGAG CCGCCTTGCT CCGTACCTTC AGCTTTTTGG GCTTTGAGAT TGTGAGACCG 
GGGCATCCCC TTGTCCCCAA GAGACCCGAC GCTTGCTTCA TGGCCTACAC GTTTGAGAGA 
GAGTCCTCTG GTGAGGAGGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Molecular characterization, tissue expression and nucleotide variation of the porcine AZ1 gene.
Gene501(1)79-84(2012 Jun)
Zhang AL,Wu XY,Li JQ,Zhang Z,Zhang H

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Nucleic acids research35(6)1842-58(2007)
Ivanov IP,Atkins JF

Porcine transcriptome analysis based on 97 non-normalized cDNA libraries and assembly of 1,021,891 expressed sequence tags.
Genome biology8(4)R45(2007)
Gorodkin J,Cirera S,Hedegaard J,Gilchrist MJ,Panitz F,J?rgensen C,Scheibye-Knudsen K,Arvin T,Lumholdt S,Sawera M,Green T,Nielsen BJ,Havgaard JH,Rosenkilde C,Wang J,Li H,Li R,Liu B,Hu S,Dong W,Li W,Yu J,Wang J,Staefeldt HH,Wernersson R,Madsen LB,Thomsen B,Hornsh?j H,Bujie Z,Wang X,Wang X,Bolund L,Brunak S,Yang H,Bendixen C,Fredholm M

PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences.
Nucleic acids research35(Database issue)D650-3(2007 Jan)
Uenishi H,Eguchi-Ogawa T,Shinkai H,Okumura N,Suzuki K,Toki D,Hamasima N,Awata T

Mitochondrial localization of antizyme is determined by context-dependent alternative utilization of two AUG initiation codons.
Mitochondrion2(4)245-56(2003 Mar)
Gandre S,Bercovich Z,Kahana C

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OAZ1 cDNA ORF clone, Sus scrofa(pig)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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