Gene Symbol | top2 |
Entrez Gene ID | 2540541 |
Full Name | DNA topoisomerase II |
Gene Type | protein-coding |
Organism | Schizosaccharomyces pombe(fission yeast) |
ORF » Species Summary » Schizosaccharomyces pombe » top2 cDNA ORF clone
Gene Symbol | top2 |
Entrez Gene ID | 2540541 |
Full Name | DNA topoisomerase II |
Gene Type | protein-coding |
Organism | Schizosaccharomyces pombe(fission yeast) |
mRNA | Protein | Name |
---|---|---|
NM_001021708.2 | NP_595805.1 | DNA topoisomerase II |
Saccharomyces cerevisiae (baker's yeast) | TOP2 | NP_014311.3 |
Schizosaccharomyces pombe (fission yeast) | top2 | NP_595805.1 |
Oryza sativa (rice) | Os02g0699700 | NP_001047833.1 |
Pan troglodytes (chimpanzee) | TOP2B | XP_516332.3 |
TOP2B | XP_001092092.2 | |
Gallus gallus (chicken) | TOP2B | NP_990413.1 |
Neurospora crassa | NCU06338 | XP_962372.2 |
Danio rerio (zebrafish) | top2b | NP_001038656.1 |
Bos taurus (cattle) | TOP2B | XP_002698796.2 |
Mus musculus (house mouse) | Top2b | NP_033435.2 |
Magnaporthe oryzae (rice blast fungus) | MGG_06162 | XP_003712042.1 |
Arabidopsis thaliana (thale cress) | TOPII | NP_001118686.1 |
Homo sapiens (human) | TOP2B | NP_001059.2 |
Canis lupus familiaris (dog) | TOP2B | XP_534241.3 |
Rattus norvegicus (Norway rat) | Top2b | NP_001094328.1 |
Kluyveromyces lactis | KLLA0C13838g | XP_452818.1 |
Eremothecium gossypii | AGOS_AER410W | NP_985265.1 |
Xenopus tropicalis (tropical clawed frog) | top2b | XP_004915443.1 |
The genome sequence of Schizosaccharomyces pombe.
Wood V, Gwilliam R, Rajandream MA, Lyne M, Lyne R, Stewart A, Sgouros J, Peat N, Hayles J, Baker S, Basham D, Bowman S, Brooks K, Brown D, Brown S, Chillingworth T, Churcher C, Collins M, Connor R, Cronin A, Davis P, Feltwell T, Fraser A, Gentles S, Goble A, Hamlin N, Harris D, Hidalgo J, Hodgson G, Holroyd S, Hornsby T, Howarth S, Huckle EJ, Hunt S, Jagels K, James K, Jones L, Jones M, Leather S, McDonald S, McLean J, Mooney P, Moule S, Mungall K, Murphy L, Niblett D, Odell C, Oliver K, O'Neil S, Pearson D, Quail MA, Rabbinowitsch E, Rutherford K, Rutter S, Saunders D, Seeger K, Sharp S, Skelton J, Simmonds M, Squares R, Squares S, Stevens K, Taylor K, Taylor RG, Tivey A, Walsh S, Warren T, Whitehead S, Woodward J, Volckaert G, Aert R, Robben J, Grymonprez B, Weltjens I, Vanstreels E, Rieger M, Sch?fer M, M?ller-Auer S, Gabel C, Fuchs M, D?sterh?ft A, Fritzc C, Holzer E, Moestl D, Hilbert H, Borzym K, Langer I, Beck A, Lehrach H, Reinhardt R, Pohl TM, Eger P, Zimmermann W, Wedler H, Wambutt R, Purnelle B, Goffeau A, Cadieu E, Dr?ano S, Gloux S, Lelaure V, Mottier S, Galibert F, Aves SJ, Xiang Z, Hunt C, Moore K, Hurst SM, Lucas M, Rochet M, Gaillardin C, Tallada VA, Garzon A, Thode G, Daga RR, Cruzado L, Jimenez J, S?nchez M, del Rey F, Benito J, Dom?nguez A, Revuelta JL, Moreno S, Armstrong J, Forsburg SL, Cerutti L, Lowe T, McCombie WR, Paulsen I, Potashkin J, Shpakovski GV, Ussery D, Barrell BG, Nurse P, Cerrutti L
Nature415(6874)871-80(2002 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Rrp2 possesses SUMO-binding ability and prevents excessive Top2 degradation by competing against the SUMO-targeted ubiquitin ligase (STUbL) for SUMO chain binding and by displacing SUMOylated Top2 from DNA.
Title: SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage.
DNA topoisomerase 2 mutant allele mildly delays the mitotic progression and activates the checkpoint protein kinase Chk1 in fission yeast Schizosaccharomyces pombe.
Title: DNA topoisomerase 2 mutant allele mildly delays the mitotic progression and activates the checkpoint protein kinase Chk1 in fission yeast Schizosaccharomyces pombe.
topoisomerase II has a role in disentangling dysfunctional telomeres
Title: A non-canonical function of topoisomerase II in disentangling dysfunctional telomeres.
Schizosaccharomyces pombe Rad32(Mre11) nuclease activity is involved in the removal of both Top2 from 5' DNA ends as well as Top1 from 3' ends in vivo and a ctp1(CtIP) deletion is defective for Top2 removal but overproficient for Top1 removal.
Title: Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.
The following top2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the top2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSc100712 | |
Clone ID Related Accession (Same CDS sequence) | NM_001021708.2 | |
Accession Version | NM_001021708.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4458bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-04-02 | |
Organism | Schizosaccharomyces pombe(fission yeast) | |
Product | DNA topoisomerase II | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. This record is derived from an annotated genomic sequence (NC_003423). On Dec 10, 2012 this sequence version replaced NM_001021708.1. |
1 | ATGTCCATTG ATGCGGATTT CTCCGACTAT GAAGATGAAG CGTCTGGAGA CGAAAACGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_595805.1 |
CDS | 2077..6534 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001021708.2 |
1 | ATGTCCATTG ATGCGGATTT CTCCGACTAT GAAGATGAAG CGTCTGGAGA CGAAAACGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The genome sequence of Schizosaccharomyces pombe. |