Gene Symbol | chk1 |
Entrez Gene ID | 2539087 |
Full Name | Chk1 protein kinase |
Gene Type | protein-coding |
Organism | Schizosaccharomyces pombe(fission yeast) |
ORF » Species Summary » Schizosaccharomyces pombe » chk1 cDNA ORF clone
Gene Symbol | chk1 |
Entrez Gene ID | 2539087 |
Full Name | Chk1 protein kinase |
Gene Type | protein-coding |
Organism | Schizosaccharomyces pombe(fission yeast) |
mRNA | Protein | Name |
---|---|---|
NM_001023062.2 | NP_588070.1 | Chk1 protein kinase |
NM_001355907.1 | NP_001342786.1 | protein kinase Chk1 |
Bos taurus (cattle) | CHEK1 | NP_001091492.1 |
Gallus gallus (chicken) | STT3A | NP_989676.1 |
Saccharomyces cerevisiae (baker's yeast) | CHK1 | NP_009833.1 |
Eremothecium gossypii | AGOS_AEL185C | NP_984676.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_03729 | XP_003716151.1 |
Xenopus tropicalis (tropical clawed frog) | chek1 | XP_002937561.2 |
Homo sapiens (human) | CHEK1 | NP_001265.2 |
Rattus norvegicus (Norway rat) | Chek1 | NP_536325.1 |
Caenorhabditis elegans (roundworm) | chk-1 | NP_001024233.1 |
Kluyveromyces lactis | KLLA0F01276g | XP_455137.1 |
Schizosaccharomyces pombe (fission yeast) | chk1 | NP_588070.1 |
LOC713358 | XP_001111431.2 | |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP008118 | XP_317338.4 |
Pan troglodytes (chimpanzee) | CHEK1 | XP_001146296.1 |
Mus musculus (house mouse) | Chek1 | NP_031717.2 |
Neurospora crassa | NCU08346 | XP_965249.2 |
Canis lupus familiaris (dog) | CHEK1 | XP_852191.1 |
Danio rerio (zebrafish) | chek1 | NP_956487.1 |
Drosophila melanogaster (fruit fly) | grp | NP_723986.1 |
The genome sequence of Schizosaccharomyces pombe.
Wood V, Gwilliam R, Rajandream MA, Lyne M, Lyne R, Stewart A, Sgouros J, Peat N, Hayles J, Baker S, Basham D, Bowman S, Brooks K, Brown D, Brown S, Chillingworth T, Churcher C, Collins M, Connor R, Cronin A, Davis P, Feltwell T, Fraser A, Gentles S, Goble A, Hamlin N, Harris D, Hidalgo J, Hodgson G, Holroyd S, Hornsby T, Howarth S, Huckle EJ, Hunt S, Jagels K, James K, Jones L, Jones M, Leather S, McDonald S, McLean J, Mooney P, Moule S, Mungall K, Murphy L, Niblett D, Odell C, Oliver K, O'Neil S, Pearson D, Quail MA, Rabbinowitsch E, Rutherford K, Rutter S, Saunders D, Seeger K, Sharp S, Skelton J, Simmonds M, Squares R, Squares S, Stevens K, Taylor K, Taylor RG, Tivey A, Walsh S, Warren T, Whitehead S, Woodward J, Volckaert G, Aert R, Robben J, Grymonprez B, Weltjens I, Vanstreels E, Rieger M, Sch?fer M, M?ller-Auer S, Gabel C, Fuchs M, D?sterh?ft A, Fritzc C, Holzer E, Moestl D, Hilbert H, Borzym K, Langer I, Beck A, Lehrach H, Reinhardt R, Pohl TM, Eger P, Zimmermann W, Wedler H, Wambutt R, Purnelle B, Goffeau A, Cadieu E, Dr?ano S, Gloux S, Lelaure V, Mottier S, Galibert F, Aves SJ, Xiang Z, Hunt C, Moore K, Hurst SM, Lucas M, Rochet M, Gaillardin C, Tallada VA, Garzon A, Thode G, Daga RR, Cruzado L, Jimenez J, S?nchez M, del Rey F, Benito J, Dom?nguez A, Revuelta JL, Moreno S, Armstrong J, Forsburg SL, Cerutti L, Lowe T, McCombie WR, Paulsen I, Potashkin J, Shpakovski GV, Ussery D, Barrell BG, Nurse P, Cerrutti L
Nature415(6874)871-80(2002 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
chk1- and wat1-null mutants exhibit conditional synthetic lethality.
Title: Activation of Checkpoint Kinase Chk1 by Reactive Oxygen Species Resulting from Disruption of wat1/pop3 in Schizosaccharomyces pombe.
The isolation of a mutant allele of rna14 in Schizosaccharomyces pombe has been reported that exhibits reduction in protein level of Chk1 at the nonpermissive temperature, primarily due to the defects in posttranscriptional processing.
Title: Mutant allele of rna14 in fission yeast affects pre-mRNA splicing.
Rad4 mainly functions as a scaffold protein in the Chk1, not the Cds1(CHK2 in humans), checkpoint pathway. It plays a minor role or is functionally redundant with an unknown factor in Rad3 activation.
Title: Rad4 mainly functions in Chk1-mediated DNA damage checkpoint pathway as a scaffold protein in the fission yeast Schizosaccharomyces pombe.
The combination of wat1-17 with the chk1 deletion aggravates the defects in the maintenance of fungal genome ploidy.
Title: Wat1/pop3, a conserved WD repeat containing protein acts synergistically with checkpoint kinase Chk1 to maintain genome ploidy in fission yeast S. pombe.
The following chk1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the chk1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSj00435 | |
Clone ID Related Accession (Same CDS sequence) | NM_001023062.2 | |
Accession Version | NM_001023062.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1491bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2013-04-30 | |
Organism | Schizosaccharomyces pombe 972h- | |
Product | Chk1 protein kinase | |
Comment | PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. This record is derived from an annotated genomic sequence (NC_003421). On Dec 10, 2012 this sequence version replaced NM_001023062.1. Notes: S. pombe (fission yeast) sequence and annotation are available from: (URL, http://www.genedb.org/genedb/pombe/index.jsp) (URL, http://www.sanger.ac.uk/Projects/S_pombe/) CDS are numbered using the following system eg SPAC5H10.01c. SP (S. pombe), A (chromosome 1), c5H10 (cosmid name), .01 (first CDS), c (complementary strand). However, clones may have been reorientated since the original submission, therefore the complementary strand notation may be invalid for strand inference. |
1 | ATGGCTCAAA AATTAGATAA CTTTCCTTAC CATATTGGTA GAGAAATAGG TACTGGGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_588070.1 |
CDS | 222..1712 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001023062.2 |
1 | ATGGCTCAAA AATTAGATAA CTTTCCTTAC CATATTGGTA GAGAAATAGG TACTGGGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OSc99595 | |
Clone ID Related Accession (Same CDS sequence) | NM_001355907.1 | |
Accession Version | NM_001355907.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1491bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-04-02 | |
Organism | Schizosaccharomyces pombe(fission yeast) | |
Product | protein kinase Chk1 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. This record is derived from an annotated genomic sequence (NC_003421). |
1 | ATGGCTCAAA AATTAGATAA CTTTCCTTAC CATATTGGTA GAGAAATAGG TACTGGGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001342786.1 |
CDS | 222..1712 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001355907.1 |
1 | ATGGCTCAAA AATTAGATAA CTTTCCTTAC CATATTGGTA GAGAAATAGG TACTGGGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The genome sequence of Schizosaccharomyces pombe. |