Gene Symbol | MCM4 |
Entrez Gene ID | 856130 |
Full Name | MCM DNA helicase complex subunit MCM4 |
Synonyms | CDC54,HCD21 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » MCM4 cDNA ORF clone
Gene Symbol | MCM4 |
Entrez Gene ID | 856130 |
Full Name | MCM DNA helicase complex subunit MCM4 |
Synonyms | CDC54,HCD21 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001184116.1 | NP_015344.1 | MCM DNA helicase complex subunit MCM4 |
Gallus gallus (chicken) | MCM4 | XP_424376.2 |
Arabidopsis thaliana (thale cress) | MCM4 | NP_179236.3 |
Pan troglodytes (chimpanzee) | MCM4 | XP_528129.2 |
Canis lupus familiaris (dog) | MCM4 | XP_535063.3 |
Mus musculus (house mouse) | Mcm4 | NP_032591.3 |
Rattus norvegicus (Norway rat) | Mcm4 | NP_387500.1 |
Eremothecium gossypii | AGOS_ADL026W | NP_984071.2 |
Magnaporthe oryzae (rice blast fungus) | MGG_09293 | XP_003709942.1 |
Xenopus tropicalis (tropical clawed frog) | mcm4 | NP_001005655.1 |
Bos taurus (cattle) | MCM4 | NP_001068626.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP004956 | XP_315054.2 |
Homo sapiens (human) | MCM4 | NP_005905.2 |
MCM4 | XP_002805376.1 | |
Danio rerio (zebrafish) | mcm4 | NP_944595.2 |
Schizosaccharomyces pombe (fission yeast) | mcm4 | NP_588004.2 |
Drosophila melanogaster (fruit fly) | dpa | NP_477185.1 |
Caenorhabditis elegans (roundworm) | mcm-4 | NP_490962.1 |
Saccharomyces cerevisiae (baker's yeast) | MCM4 | NP_015344.1 |
Kluyveromyces lactis | KLLA0C17512g | XP_452982.1 |
Neurospora crassa | NCU02539 | XP_965670.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
Bussey H, Storms RK, Ahmed A, Albermann K, Allen E, Ansorge W, Araujo R, Aparicio A, Barrell B, Badcock K, Benes V, Botstein D, Bowman S, Br?ckner M, Carpenter J, Cherry JM, Chung E, Churcher C, Coster F, Davis K, Davis RW, Dietrich FS, Delius H, DiPaolo T, Hani J
Nature387(6632 Suppl)103-5(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Sld3 binds specifically to DDK-phosphorylated peptides from two MCM subunits (Mcm4, 6) and then recruits Cdc45.
Title: Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation.
The Dbf4-dependent Cdc7 kinase (DDK), cyclin-dependent kinase (CDK), and Mec1 all target the structurally disordered N-terminal serine/threonine-rich domain of Mcm4, a subunit of the mini-chromosome maintenance replicative helicase complex.
Title: Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.
constitutive overexpression of each individual MCM subunit was examined, and genotoxic sensitivity was found to be specific to Mcm2 or Mcm4 overexpression, further pointing to the importance of the DDK-MCM ring interaction.
Title: Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits.
A defective MCM helicase causes genetic instability only in particular cell types.
Title: Ploidy dictates repair pathway choice under DNA replication stress.
The minimal functional unit of Mcm4/6/7 is a hexamer
Title: The effects of oligomerization on Saccharomyces cerevisiae Mcm4/6/7 function.
The following MCM4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MCM4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi04980 | |
Clone ID Related Accession (Same CDS sequence) | NM_001184116.1 | |
Accession Version | NM_001184116.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2802bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | MCM DNA helicase complex subunit MCM4 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001148). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGTCTCAAC AGTCTAGCTC TCCAACAAAA GAGGATAATA ACTCCAGCTC CCCCGTTGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_015344.1 |
CDS | 1..2802 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001184116.1 |
1 | ATGTCTCAAC AGTCTAGCTC TCCAACAAAA GAGGATAATA ACTCCAGCTC CCCCGTTGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI. |
Life with 6000 genes. |